+Gz暴露对大鼠记忆功能和行为的影响
http://www.100md.com
2005年2月26日
+Gz暴露对大鼠记忆功能和行为的影响
韦应波 孙喜庆 曹新生 姚永杰 张晓军*
(710032 西安，第四军医大学航空航天医学系航空航天生物动力学教研室，*生物医学工程系物理学教研室)
【摘要】 目的 探讨不同水平+Gz暴露对大鼠记忆功能和行为的影响。 方法 24只雄性SD大鼠随机分为对照组、+6 Gz组和+10 Gz组3组，每组8只。+Gz暴露大鼠分别进行+6 Gz/3 min和+10 Gz/3 min暴露，记录+Gz暴露后不同时间大鼠记忆功能和行为的变化。 结果 与对照组比较，+10 Gz组大鼠反应时在+Gz暴露后即刻和2 d时显著延长(P<0.01)，错误次数及错误时间在+Gz暴露后6 h时显著增加(P<0.01)，中央格内停留时间在+Gz暴露后即刻、6 h和1 d时显著延长(P<0.01)，站立次数和跨格次数则在+Gz暴露后即刻和2 d时显著减少(P<0.01)；而+6 Gz组大鼠仅站立次数在+Gz暴露后即刻和2 d时较对照组显著减少(P<0.01)， 其余指标均无显著性差异。 结论 +10 Gz/3 min暴露可引起暂时性大鼠记忆功能降低和行为改变。
【关键词】 加速度；行为；记忆；大鼠
【中图分类号】 R852.21
Effect of +Gz exposure on memory and behavior in rats WEI Ying-bo， SUN Xi-qing， CAO Xin-sheng， et al. Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an 710032， China
【Abstract】 Objective To explore the effect of +Gz exposure of different magnitudes on memory and behavior in rats. Methods Twentyfour male SD rats were randomly divided into three groups: control group，+6 Gz and +10 Gz groups. The rats of +Gz groups were exposed to +6 Gz and +10 Gz for 3 min respectively. The memory and behavior in rats were measured before and after +Gz exposures. Results As compared with that of control, reaction time prolonged significantly immediately and 1 day after +10 Gz exposure (P<0.01); number of errors and time of errors increased significantly 6 hours after +10 Gz exposure (P<0.01); time of stay in center grille prolonged significantly immediately， 6 hours and 2 days after +10 Gz exposure (P<0.01); number of rearing and number of crossing decreased significantly immediately and 2 days after +10 Gz exposure (P<0.01); number of rearing decreased significantly immediately and 2 days after +6 Gz exposure (P<0.01). Conclusions It is suggested that +10 Gz/3 min exposure may induce temporary disturbance of memory function and changes of behavior in rats.
【Key words】 Acceleration; Behavior; Memory; Rat, 百拇医药
韦应波 孙喜庆 曹新生 姚永杰 张晓军*
(710032 西安，第四军医大学航空航天医学系航空航天生物动力学教研室，*生物医学工程系物理学教研室)
【摘要】 目的 探讨不同水平+Gz暴露对大鼠记忆功能和行为的影响。 方法 24只雄性SD大鼠随机分为对照组、+6 Gz组和+10 Gz组3组，每组8只。+Gz暴露大鼠分别进行+6 Gz/3 min和+10 Gz/3 min暴露，记录+Gz暴露后不同时间大鼠记忆功能和行为的变化。 结果 与对照组比较，+10 Gz组大鼠反应时在+Gz暴露后即刻和2 d时显著延长(P<0.01)，错误次数及错误时间在+Gz暴露后6 h时显著增加(P<0.01)，中央格内停留时间在+Gz暴露后即刻、6 h和1 d时显著延长(P<0.01)，站立次数和跨格次数则在+Gz暴露后即刻和2 d时显著减少(P<0.01)；而+6 Gz组大鼠仅站立次数在+Gz暴露后即刻和2 d时较对照组显著减少(P<0.01)， 其余指标均无显著性差异。 结论 +10 Gz/3 min暴露可引起暂时性大鼠记忆功能降低和行为改变。
【关键词】 加速度；行为；记忆；大鼠
【中图分类号】 R852.21
Effect of +Gz exposure on memory and behavior in rats WEI Ying-bo， SUN Xi-qing， CAO Xin-sheng， et al. Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an 710032， China
【Abstract】 Objective To explore the effect of +Gz exposure of different magnitudes on memory and behavior in rats. Methods Twentyfour male SD rats were randomly divided into three groups: control group，+6 Gz and +10 Gz groups. The rats of +Gz groups were exposed to +6 Gz and +10 Gz for 3 min respectively. The memory and behavior in rats were measured before and after +Gz exposures. Results As compared with that of control, reaction time prolonged significantly immediately and 1 day after +10 Gz exposure (P<0.01); number of errors and time of errors increased significantly 6 hours after +10 Gz exposure (P<0.01); time of stay in center grille prolonged significantly immediately， 6 hours and 2 days after +10 Gz exposure (P<0.01); number of rearing and number of crossing decreased significantly immediately and 2 days after +10 Gz exposure (P<0.01); number of rearing decreased significantly immediately and 2 days after +6 Gz exposure (P<0.01). Conclusions It is suggested that +10 Gz/3 min exposure may induce temporary disturbance of memory function and changes of behavior in rats.
【Key words】 Acceleration; Behavior; Memory; Rat, 百拇医药