BFGF，BFGFR和COX-2与大肠癌的关系
韦良宏,林瑶光,广西医科大学第一附属医院老年消化内科 广西壮族自治区南宁市 530021
广西科技厅科研基金资助课题(桂科基), No.0342010-4
项目负责人: 林瑶光, 530021, 广西壮族自治区南宁市, 广西医科大学第一附属医院老年消化内科.
电话: 0771-5356596
收稿日期: 2004-12-10 接受日期: 2005-01-05
摘要碱性成纤维细胞生长因子(BFGF)，BFGF受体(BFGFR)和环氧合酶-2(COX-2)在大肠癌中的表达增加，他们与大肠癌的相关性越来越受到人们的关注.但其确切机制仍然不清楚.现就BFGF，BFGFR及COX-2的结构与功能，及其在大肠癌的表达及促癌机制等方面进行综述.
, 百拇医药
韦良宏, 林瑶光. BFGF，BFGFR 和COX-2与大肠癌的关系. 世界华人消化杂志 2005;13(5):667-6701 Okada-Ban M, Thiery JP, Jouanneau J. Fibroblast growth factor-2. Int J Biochem Cell Biol 2000;32:263-267
2 蒋志文. 碱性成纤维细胞生长因子受体的调节. 蚌埠医学院学报 1997;22:367-368
3 Dow JK, deVere White RW. Fibroblast growth factor 2: its structureand property, paracrine function, tumor
angiogenesis, and prostate-relatedmitogenic and oncogenic functions. Urology 2000;55:800-806
, 百拇医药
4 Oppenheim J, Fujiwara H. The role of cytokines in cancer. Cytokine Growth Factor Rev 1996;7:279-288
5 尚海, 单吉贤, 高红, 张颐. 大肠癌组织中aFGF bFGF及FGFR1表达水平的研究. 中国肿瘤临床 2003;30:424-427
6 陈江, 向军俭, 祝金泉, 黄德强, 张|KUN|和, 谢勇, 王崇文. 碱性成纤维细胞生长因子在恶性肿瘤细胞中
表达状况及其意义. 中国现代医学杂志 2001;11:25-27
7 Smith K, Fox SB, Whitehouse R, Taylor M, Greenall M, Clarke J,Harris AL. Upregulation of basic fibroblast growth
, 百拇医药
factor in breast carcinoma and itsrelationship to vascular density, oestrogen receptor, epidermal growthfactor
receptor and survival. Ann Oncol 1999;10:707-713
8 Weerda HG, Gamberger TI, Siegner A, Gjuric M, Tamm ER. Effects oftransforming growth factor-beta1 and basic
fibroblast growth factor on proliferationof cell cultures derived from human vestibular nerve schwannoma.
, http://www.100md.com
Acta Otolaryngol 1998;118:337-343
9 孙爱静, 贾心善, 西川克三, 吉竹佳乃. bFGF及其受体在人大肠癌细胞中的表达和意义.
中国医科大学学报 1998;27:441-444
10 New BA, Yeoman LC. Identification of basic fibroblast growth factorsensitivity and receptor and ligand expression
in human colon tumor cell lines. J Cell Physiol 1992;150:320-326
11 Li D, Bell J, Brown A, Berry CL. The observation of angiogenin andbasic fibroblast growth factor gene expression
, 百拇医药
in human colonic adenocarcinomas,gastric adenocarcinomas, and hepatocellular carcinomas. J Pathol
1994;172:171-175
12 周廷冲. 多肽生长因子基础与临床. 北京:中国科学技术出版社, 1992:45-47
13 Langenbach R, Loftin C, Lee C, Tiano H. Cyclooxygenase knockoutmice:models for elucidating isoform-specific
functions. Biochem Pharmacol 1999;58:1237-1246
, 百拇医药 14 Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N,Jennette JC, Mahler JF, Kluckman KD, Ledford A,Lee CA. Prostaglandin synthase 2 genedisruption causes severe renal pathology in the mouse. Cell 1995;83:473-482
15 王兴鹏, 徐选福, 王冰娴, 谢传高, 吴恺, 董育玮. 环氧合酶2在胰腺癌中表达及其抑制剂对肿瘤生长的
抑制作用. 中华肝胆外科杂志 2003;9:489-491
16 Wulfing C, Eltze E, von Struensee D, Wulfing P, Hertle L, PiechotaH. Cyclooxygenase-2 expression in bladder
, 百拇医药
cancer: correlation with poor outcomeafter chemotherapy. Eur Urol 2004;45:46-52
17 Smalley WE, DuBois RN. Colorectal cancer and nonsteroidalanti-inflammatory drugs. Adv Pharmacol 1997;39:1-20
18 Tsunozaki H, Yoshinaga K, Kumagai J, Sugihara K. Cyclooxygenase-2overexpression in colorectal cancer is associated
with non-polypoid growth. Jpn J Clin Oncol 2002;32:167-171
, 百拇医药
19 Sheehan KM, Sheahan K, O'DonoghueDP, MacSweeney F, Conroy RM, Fitzgerald DJ, Murray FE. The relationship
between cyclooxygenase-2 expressionand colorectal cancer. JAMA 1999;282:1254-1257
20 潘赛英, 胡跃, 张苏展, 陈丽荣, 王海军. 环氧化酶-2表达与大肠癌TNM分期、分化及转移之间的关系.
中国肿瘤杂志 2004;26:300
21 艾志龙, 陆维祺, 许建芳, 阿克苏. 环氧合酶-2在人结直肠肿瘤中的表达及其临床意义.
中国癌症杂志 2003;13:138-140
, 百拇医药
22 Dimberg J, Samuelsson A, Hugander A, Soderkvist P. Differentialexpression of cyclooxygenase 2 in human
colorectal cancer. Gut 1999;45:730-732
23 Konno H, Baba M, Shoji T, Ohta M, Suzuki S, Nakamura S.Cyclooxygenase-2 expression correlates with uPAR levels
and is responsible for poor prognosisof colorectal cancer. Clin Exp Metastasis 2002;19:527-534
, 百拇医药 24 Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-674
25 Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ,Tarnawski AS. Inhibition of angiogenesis by nonsteroidal
anti-inflammatory drugs:insight intomechanisms and implications for cancer growth and ulcer healing. Nat Med
1999;5:1418-1423
26 O'MahonyCA, Beauchamp RD, Albo D, Tsujii M, Sheng HM, Shao J, Dubois RN, BergerDH. Cyclooxygenase-2
, http://www.100md.com
alters transforming growthfactor-beta 1 response during intestinal tumorigenesis. Surgery 1999;126:364-370
27 Kawamori T, Rao CV, Seibert K, Reddy BS. Chemopreventive activityof celecoxib, a specific cyclooxygenase-2
inhibitor, against coloncarcinogenesis. Cancer Res 1998;58:409-412
28 Kakiuchi Y, Tsuji S, Tsujii M, Murata H, Kawai N, Yasumaru M,Kimura A, Komori M, Irie T, Miyoshi E, Sasaki Y,Hayashi N, Kawano S, Hori M.Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigenson colon
cancer cells and enhanced livermetastasis. Cancer Res 2002;62:1567-1572
29 Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN.Cyclooxygenase regulates angiogenesis induced by
colon cancer cells. Cell 1998;93:705-716
编辑 潘伯荣 审读 张海宁, http://www.100md.com( 韦良宏,林瑶光)
广西科技厅科研基金资助课题(桂科基), No.0342010-4
项目负责人: 林瑶光, 530021, 广西壮族自治区南宁市, 广西医科大学第一附属医院老年消化内科.
电话: 0771-5356596
收稿日期: 2004-12-10 接受日期: 2005-01-05
摘要碱性成纤维细胞生长因子(BFGF)，BFGF受体(BFGFR)和环氧合酶-2(COX-2)在大肠癌中的表达增加，他们与大肠癌的相关性越来越受到人们的关注.但其确切机制仍然不清楚.现就BFGF，BFGFR及COX-2的结构与功能，及其在大肠癌的表达及促癌机制等方面进行综述.
, 百拇医药
韦良宏, 林瑶光. BFGF，BFGFR 和COX-2与大肠癌的关系. 世界华人消化杂志 2005;13(5):667-6701 Okada-Ban M, Thiery JP, Jouanneau J. Fibroblast growth factor-2. Int J Biochem Cell Biol 2000;32:263-267
2 蒋志文. 碱性成纤维细胞生长因子受体的调节. 蚌埠医学院学报 1997;22:367-368
3 Dow JK, deVere White RW. Fibroblast growth factor 2: its structureand property, paracrine function, tumor
angiogenesis, and prostate-relatedmitogenic and oncogenic functions. Urology 2000;55:800-806
, 百拇医药
4 Oppenheim J, Fujiwara H. The role of cytokines in cancer. Cytokine Growth Factor Rev 1996;7:279-288
5 尚海, 单吉贤, 高红, 张颐. 大肠癌组织中aFGF bFGF及FGFR1表达水平的研究. 中国肿瘤临床 2003;30:424-427
6 陈江, 向军俭, 祝金泉, 黄德强, 张|KUN|和, 谢勇, 王崇文. 碱性成纤维细胞生长因子在恶性肿瘤细胞中
表达状况及其意义. 中国现代医学杂志 2001;11:25-27
7 Smith K, Fox SB, Whitehouse R, Taylor M, Greenall M, Clarke J,Harris AL. Upregulation of basic fibroblast growth
, 百拇医药
factor in breast carcinoma and itsrelationship to vascular density, oestrogen receptor, epidermal growthfactor
receptor and survival. Ann Oncol 1999;10:707-713
8 Weerda HG, Gamberger TI, Siegner A, Gjuric M, Tamm ER. Effects oftransforming growth factor-beta1 and basic
fibroblast growth factor on proliferationof cell cultures derived from human vestibular nerve schwannoma.
, http://www.100md.com
Acta Otolaryngol 1998;118:337-343
9 孙爱静, 贾心善, 西川克三, 吉竹佳乃. bFGF及其受体在人大肠癌细胞中的表达和意义.
中国医科大学学报 1998;27:441-444
10 New BA, Yeoman LC. Identification of basic fibroblast growth factorsensitivity and receptor and ligand expression
in human colon tumor cell lines. J Cell Physiol 1992;150:320-326
11 Li D, Bell J, Brown A, Berry CL. The observation of angiogenin andbasic fibroblast growth factor gene expression
, 百拇医药
in human colonic adenocarcinomas,gastric adenocarcinomas, and hepatocellular carcinomas. J Pathol
1994;172:171-175
12 周廷冲. 多肽生长因子基础与临床. 北京:中国科学技术出版社, 1992:45-47
13 Langenbach R, Loftin C, Lee C, Tiano H. Cyclooxygenase knockoutmice:models for elucidating isoform-specific
functions. Biochem Pharmacol 1999;58:1237-1246
, 百拇医药 14 Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N,Jennette JC, Mahler JF, Kluckman KD, Ledford A,Lee CA. Prostaglandin synthase 2 genedisruption causes severe renal pathology in the mouse. Cell 1995;83:473-482
15 王兴鹏, 徐选福, 王冰娴, 谢传高, 吴恺, 董育玮. 环氧合酶2在胰腺癌中表达及其抑制剂对肿瘤生长的
抑制作用. 中华肝胆外科杂志 2003;9:489-491
16 Wulfing C, Eltze E, von Struensee D, Wulfing P, Hertle L, PiechotaH. Cyclooxygenase-2 expression in bladder
, 百拇医药
cancer: correlation with poor outcomeafter chemotherapy. Eur Urol 2004;45:46-52
17 Smalley WE, DuBois RN. Colorectal cancer and nonsteroidalanti-inflammatory drugs. Adv Pharmacol 1997;39:1-20
18 Tsunozaki H, Yoshinaga K, Kumagai J, Sugihara K. Cyclooxygenase-2overexpression in colorectal cancer is associated
with non-polypoid growth. Jpn J Clin Oncol 2002;32:167-171
, 百拇医药
19 Sheehan KM, Sheahan K, O'DonoghueDP, MacSweeney F, Conroy RM, Fitzgerald DJ, Murray FE. The relationship
between cyclooxygenase-2 expressionand colorectal cancer. JAMA 1999;282:1254-1257
20 潘赛英, 胡跃, 张苏展, 陈丽荣, 王海军. 环氧化酶-2表达与大肠癌TNM分期、分化及转移之间的关系.
中国肿瘤杂志 2004;26:300
21 艾志龙, 陆维祺, 许建芳, 阿克苏. 环氧合酶-2在人结直肠肿瘤中的表达及其临床意义.
中国癌症杂志 2003;13:138-140
, 百拇医药
22 Dimberg J, Samuelsson A, Hugander A, Soderkvist P. Differentialexpression of cyclooxygenase 2 in human
colorectal cancer. Gut 1999;45:730-732
23 Konno H, Baba M, Shoji T, Ohta M, Suzuki S, Nakamura S.Cyclooxygenase-2 expression correlates with uPAR levels
and is responsible for poor prognosisof colorectal cancer. Clin Exp Metastasis 2002;19:527-534
, 百拇医药 24 Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-674
25 Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ,Tarnawski AS. Inhibition of angiogenesis by nonsteroidal
anti-inflammatory drugs:insight intomechanisms and implications for cancer growth and ulcer healing. Nat Med
1999;5:1418-1423
26 O'MahonyCA, Beauchamp RD, Albo D, Tsujii M, Sheng HM, Shao J, Dubois RN, BergerDH. Cyclooxygenase-2
, http://www.100md.com
alters transforming growthfactor-beta 1 response during intestinal tumorigenesis. Surgery 1999;126:364-370
27 Kawamori T, Rao CV, Seibert K, Reddy BS. Chemopreventive activityof celecoxib, a specific cyclooxygenase-2
inhibitor, against coloncarcinogenesis. Cancer Res 1998;58:409-412
28 Kakiuchi Y, Tsuji S, Tsujii M, Murata H, Kawai N, Yasumaru M,Kimura A, Komori M, Irie T, Miyoshi E, Sasaki Y,Hayashi N, Kawano S, Hori M.Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigenson colon
cancer cells and enhanced livermetastasis. Cancer Res 2002;62:1567-1572
29 Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN.Cyclooxygenase regulates angiogenesis induced by
colon cancer cells. Cell 1998;93:705-716
编辑 潘伯荣 审读 张海宁, http://www.100md.com( 韦良宏,林瑶光)
