基质金属蛋白酶-9与创面修复
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MMP-9;创面修复;展望,Matrixmetallo-proteinase-9andwoundrepair,龚加庆李雅方驰华
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Matrix metallo-proteinase-9 and wound repair
龚加庆 李雅 方驰华
摘 要：MMP-9是金属蛋白酶家族中分子量最大的酶,它受许多细胞因子的调节.目前认为细胞外基质的降解在很大程度上取决金属蛋白酶与其抑制剂的平衡.MMP-9可作用较广泛的底物,在创面修复中起到重要作用,但在各种创面如急性创面、感染创面和慢性创面中的含量及相应作用有所不同,并且从某种程度上说MMP-9在创面渗液中的含量对创面的愈合趋势有一定的预测作用.对MMP-9的深入研究必将有助于攻克创面愈合中的种种难题.
关键词：MMP-9;创面修复;展望
分类号：Q556.9 文献标识码：A
文章编号：1001-0726(2003)03-0242-05
基金项目：全军医学科研"十五"计划面上项目资助(01MA134)
作者简介：龚加庆(1971- ),男(汉族),湖南常德人,1994年毕业于第一军医大学,医学硕士,主治医师.李雅(1972- ),女(汉族),湖北金山市人,1993年毕业于第三军医大学,主治医师.方驰华(1958- ),男(汉族),西安市人,第四军医大学毕业,科主任,主任医师.
作者单位：龚加庆(成都军区总医院全军普外中心,四川,成都,610083)
李雅(成都军区总医院全军普外中心,四川,成都,610083)
方驰华(第一军医大学珠江医院普通外科,广东,广州,510082)
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