端粒、端粒酶与再生
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端粒;端粒酶;增生;修复;再生医学,Telomere,telomeraseandregeneration,童庭辉郭力
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Telomere, telomerase and regeneration
童庭辉 郭力
摘 要：端粒位于真核细胞染色体末端,起保护染色体末端的作用.端粒酶位于端粒末端,作用是合成端粒DNA序列,以抵消或延缓端粒随细胞分裂的不断缩短.端粒酶活性的表达在一定程度上意味着细胞分裂、组织增生,甚至可以看作是损伤修复、再生的迹象.
关键词：端粒;端粒酶;增生;修复;再生医学
分类号：Q25;R641 文献标识码：A
文章编号：1001-0726(2004)01-0067-05
作者简介：童庭辉(1975-),男(汉族),江苏徐州人,1998年毕业于南京铁道医学院,在读硕士生.郭力(1957-),男(汉族),四川宜宾人,1990年第三军医大学毕业,硕士,科主任,主任医师.
作者单位：童庭辉(沪州医学院整形烧伤科,四川,泸州,646000)
郭力(沪州医学院整形烧伤科,四川,泸州,646000)
参考文献：
[1]Kim NW, Piatyszek MA, Prowse KR, et al.Specific association of human telomerase activity with immortal cells and cancer[J]. Science,1994,266:2011-2015.
[2]Blackbum EH. Structure and function of telomeres[J]. Nature, 1991,350(6319):569-573.
[3]Shore D. Telomerase and telomere-binding proteins: controlling the endgame[J]. Trends Biochem Sci,1997,22(7):233-235.
[4]Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de lange T.Mammalian telomeres end in a large duplex loop[J]. Cell,1999,97(4):503-514.
[5]Greider CW, Blackburn, EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity[J]. Cell,1987,51(6):887-898.
[6]Romero DP, Blackburn EH. A conserved secondary structure for telomerase RNA[J]. Cell,1991,67(2):343-353.
[7]Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al. The RNA component of human telomerase[J]. Science,1995,269(5228):1236-1241.
[8]Rhyu MS. Telomeres, telomerase, and immortality[J]. J Natl Cancer Inst,1995,87(12):884-894.
[9]Muller, H.J. The remaking of chromosomes[J]. Collect. Net-Woods Hole,1938,13:181-198.
[10]Blackburn EH, Gall JG. A randomly repeated sequence at the termini of extrachromosomal ribosomal RNA genes in tetrahymena[J]. J Mol Biol, 1978,120:33-53.
[11]Allshire R C, Gosden J R, Cross S H et al. Telomeric repeat from T. thermophila cross hybridizes with human telomeres[J]. Nature, 1998,332:656.
[12]Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon[J]. J Theor Biol,1973,41:181-190.
[13]Harley CB et al. Telomere loss: Mitotic clock or genetic time bomb? Mutat[J]. Res,1991,256:271-282.
[14]Harley, C.B., Futcher, A.B., and Greider, C.W. Telomeres shorten during ageing of human fibroblasts[J]. Nature,1990,345:458-460.
[15]De Lange, T., Shiue L., Myers R. M., Cox D. R., Naylor S. L., Killery A. M. and Varmus H. E. Structure and variability of human chromosome ends[J]. Mol. Cell. Biol,1990,10:518-527.
[16]Allsopp R. C., Vaziri H ......
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