端粒、端粒酶与再生
http://www.100md.com
端粒;端粒酶;增生;修复;再生医学,Telomere,telomeraseandregeneration,童庭辉郭力
第1页 |
参见附件(214KB,5页)。
Telomere, telomerase and regeneration
童庭辉 郭力
摘 要:端粒位于真核细胞染色体末端,起保护染色体末端的作用.端粒酶位于端粒末端,作用是合成端粒DNA序列,以抵消或延缓端粒随细胞分裂的不断缩短.端粒酶活性的表达在一定程度上意味着细胞分裂、组织增生,甚至可以看作是损伤修复、再生的迹象.
关键词:端粒;端粒酶;增生;修复;再生医学
分类号:Q25;R641 文献标识码:A
文章编号:1001-0726(2004)01-0067-05
作者简介:童庭辉(1975-),男(汉族),江苏徐州人,1998年毕业于南京铁道医学院,在读硕士生.郭力(1957-),男(汉族),四川宜宾人,1990年第三军医大学毕业,硕士,科主任,主任医师.
作者单位:童庭辉(沪州医学院整形烧伤科,四川,泸州,646000)
郭力(沪州医学院整形烧伤科,四川,泸州,646000)
参考文献:
[1]Kim NW, Piatyszek MA, Prowse KR, et al.Specific association of human telomerase activity with immortal cells and cancer[J]. Science,1994,266:2011-2015.
[2]Blackbum EH. Structure and function of telomeres[J]. Nature, 1991,350(6319):569-573.
[3]Shore D. Telomerase and telomere-binding proteins: controlling the endgame[J]. Trends Biochem Sci,1997,22(7):233-235.
[4]Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de lange T.Mammalian telomeres end in a large duplex loop[J]. Cell,1999,97(4):503-514.
[5]Greider CW, Blackburn, EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity[J]. Cell,1987,51(6):887-898.
[6]Romero DP, Blackburn EH. A conserved secondary structure for telomerase RNA[J]. Cell,1991,67(2):343-353.
[7]Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al. The RNA component of human telomerase[J]. Science,1995,269(5228):1236-1241.
[8]Rhyu MS. Telomeres, telomerase, and immortality[J]. J Natl Cancer Inst,1995,87(12):884-894.
[9]Muller, H.J. The remaking of chromosomes[J]. Collect. Net-Woods Hole,1938,13:181-198.
[10]Blackburn EH, Gall JG. A randomly repeated sequence at the termini of extrachromosomal ribosomal RNA genes in tetrahymena[J]. J Mol Biol, 1978,120:33-53.
[11]Allshire R C, Gosden J R, Cross S H et al. Telomeric repeat from T. thermophila cross hybridizes with human telomeres[J]. Nature, 1998,332:656.
[12]Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon[J]. J Theor Biol,1973,41:181-190.
[13]Harley CB et al. Telomere loss: Mitotic clock or genetic time bomb? Mutat[J]. Res,1991,256:271-282.
[14]Harley, C.B., Futcher, A.B., and Greider, C.W. Telomeres shorten during ageing of human fibroblasts[J]. Nature,1990,345:458-460.
[15]De Lange, T., Shiue L., Myers R. M., Cox D. R., Naylor S. L., Killery A. M. and Varmus H. E. Structure and variability of human chromosome ends[J]. Mol. Cell. Biol,1990,10:518-527.
[16]Allsopp R. C., Vaziri H ......
您现在查看是摘要介绍页,详见PDF附件(214KB,5页)。
闂傚嫭鍔掔花顒勫嫉瀹ュ懎顫ら柛锝冨妼鐢洭宕濆☉宕囩缂傚啯鍨归悵顖炴焾閵娿儱鐎诲ǎ鍥e墲娴煎懘宕i鍐繑闁绘牕宕缓鐐濮橆剚鍠呴柟瀛樼墬濠€浣圭▔閳ь剛鈧姘ㄨⅶ闁告帒妫涘▓鎴濃枖閵娿儱鏂€濞村吋鑹鹃幉鍐裁规担绛嬫綌闁靛棴鎷�
婵繐鎷� pdf闁稿繈鍔嶉弸锟� 闂傚洠鍋撻悷鏇嫹 5 缂佸鍨伴崹搴ㄦ晬閸繂甯抽悹鎰潐閺佺偤宕樺畝鈧▍銉ㄣ亹閺囩偞鍊�婵絽绻愰妵澶愬矗椤栨瑤绨板Λ鏉挎瑜帮拷10濞戞搩浜炶ⅶ闁告帪鎷�闁挎稑顦埀顒婃嫹
闂佸搫鍊稿ú銊╂偟閻戣姤鍋嬮柛顐ゅ枑缂嶁偓闁诲繒鍋熼崑妯艰姳椤掑嫬鍌ㄩ柣鏃傜帛閸熷灝霉閿濆棛鐭嬫繛鐓庣墛缁傚秹鎮€靛摜顦梺鍏肩湽閸庢煡宕戝鍥ㄥ闁靛牆瀚粈瀣叏濠靛嫬鈧牠寮搁崘鈺冣枖鐎广儱鎳愰弶褰掓偠濮樼厧浜濋柡浣侯攰閵囨劙寮村杈箲婵犮垹鐖㈤崘鎯ф櫃闂佺ǹ绻愮粔鐑藉垂閸岀偞鈷撻柛娑㈠亰閸ゃ垽鏌ㄥ☉妯肩劮妞ゆ洦鍓熼弻鍥敊缂佹﹩鍋ㄩ梺鐟扮摠閻楁粓寮崫銉﹀珰婵犻潧顑傞崑鎾愁潩鏉堚晛寮ㄩ梺鐟扮摠閸ㄥ啿饪伴幋锔芥櫖閻忕偞鍎抽悘澶娒归悪鈧崜姘跺极瑜版帒绀嗗ù鑲╄ˉ閸嬫挸顫濇潏鈺佸绩闂佸憡鑹鹃崙鐣屾濠靛洤顕辨慨妯夸含瑜板矂鏌涘Δ鈧崯鍧楁儍閵忋倕绠栭柕濞у嫮鏆犳繛杈剧稻缁矂骞栬缁傛帗鎯旈姀鈩冨缂傚倸鍟崹褰掓偟椤栫偛绀嗛柣妯肩帛閻濈喖鏌曢崱顓熷
閻庣敻鍋婇崰鏇熺┍婵犲洤妫橀柛銉㈡櫇瑜帮拷
闂佺ǹ绻楀▍鏇㈠极閻愮儤鍎岄柣鎰靛墮椤庯拷
闁荤姴娲ょ€氼垶顢欓幋锕€绀勯柣妯诲絻缂嶏拷
闂佺懓鍚嬬划搴ㄥ磼閵娾晛鍗抽柡澶嬪焾濡拷
闂佽浜介崝宀勬偤閵娧呯<婵炲棙鍔栫粻娆撴煕濞嗘瑦瀚�
闂佸憡姊绘慨鎾矗閸℃稑缁╅柟顖滃椤ワ拷
|