碱性成纤维细胞生长因子(bFGF)与创伤愈合
Basic fibroblast growing factor (BFGF) and wound healing
陈佳 罗成群
创伤愈合是一复杂生物学过程,通常认为是由进入伤口的成纤维细胞增殖、分化和合成分泌,细胞外基质的纤维化,新生血管长入伤口的血管化和表皮细胞增生覆盖创面的再上皮化等综合作用的结果,而在愈合过程中产生的生长因子,包括bFGF,大多对皮肤伤口的纤维化、血管和再上皮化有介导和调控作用,可促进愈合.现将bFGF与创伤愈合的关系简要介绍如下:……
作者简介：陈佳(1979～),女(汉族),湖南长沙人,2002年湖南医学院毕业,现就读于湘雅三医院烧伤整形科硕士研究生.罗成群(1949～),男(汉族),湖南衡阳人,衡阳医学院毕业,主要从事创面修复与瘢痕预防的研究,科主任,教授,博士导师.
, http://www.100md.com
作者单位：陈佳(中南大学湘雅三医院整形烧伤科,湖南,长沙,410013)
罗成群(中南大学湘雅三医院整形烧伤科,湖南,长沙,410013)
参考文献：
[1]Vlodavsky I, Fuks Z, etal. Extracellular matrix- resident basic fibroblast growth factor: implication for the control of angiogenesis J Cell Biochem,1991,45(2):167.
[2]付小兵,现代创伤修复学[M].北京:人民军医出版社,1999:173～174.
[3]Cohen K. An overview of wound healing. In: Zieglcer TR, Pierce GF, Herndon DN, Eds. Growth factors and Wound Healing,Springer. New York, 1997: 3～7.
, 百拇医药
[4]戴方平,潘耀良,范清源,等.基因重组碱性成纤维细胞生长因子促进猪深Ⅱ度烧伤创面愈合的实验研究[J].中华整形烧伤外科杂志,1997,13(2):83～85.
[5]付小兵,沈祖尧,陈玉林,等.碱性成纤维细胞生长因子与创面修复--1024例多中心对照临床试验结果[J].中国修复重建外科杂志,1998,12(4);209～211.
[6]Smith PD, Polo M, etal. Efficacy of growth factors in the accelerated closure of interstices in explanted meshed human skin grafts. J Burn Care Rehabil.2000, 21 (1ptl): 5～9.
[7]Nissen NN, etal. Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds. Surgery. 1996, 119 (4): 457～65.
, http://www.100md.com
[8]周志钢,何清濂,林子豪,等.碱性成纤维细胞生长因子作用血管内皮细胞后c-myc基因mRNA表达的实验研究[J].中华整形外科杂志,2000:299～301.
[9]程飚,付小兵、盛志勇,等.碱性成纤维细胞生长因子对肌成纤维细胞生长的作用及其对创面愈合的影响[J].中华医学杂志,2002:1187～1191.
[10]Boulfon AJM. Clinical promise of becaplermin gel: I. Diabetic foot ulcer. 8th Amual Meeting of the European. Tissue Rapair Society,1998, 37: 27～30.
[11]Okumura M, Okudat T, etal. Effect of basic fibroblast growth factor on wound healing in healing impaired animal models. Arzneimittelforschung, 1996, 46 (5): 547～51.
, 百拇医药
[12]Okumura M, etal Accelaration of wound healing in diabetic mice by basic fibrobblast growth factor. Biol Pharm Bull, 1996, 19 (4):530 ～ 5.
[13]Fu X, Shen Z. Healing of chronic cutaneous wounds by topical treatment with basic fibrolast growth factor. Chin Med J (Engl), 2002Mar; 115 (3): 331～5.
[14]王世岭,崔晓林,付小兵,等.重组人碱性成纤维细胞生长因子治疗烧伤及皮肤损伤的临床研究[J].中华创伤杂志,1999,6:196-199.
[15]Tan EM, Rouda S, etal. Aedic and basic fibroblast growth factors down- regulate collagen gene expression in keloid fibroblasts. Am J Pathol, 1993, 142 (2): 463.
[16]徐荣祥,萧摩,烧伤皮肤再生疗法与创面愈合的机制[J].中国烧伤创疡杂志,2003,15(4):253～261., 百拇医药
陈佳 罗成群
创伤愈合是一复杂生物学过程,通常认为是由进入伤口的成纤维细胞增殖、分化和合成分泌,细胞外基质的纤维化,新生血管长入伤口的血管化和表皮细胞增生覆盖创面的再上皮化等综合作用的结果,而在愈合过程中产生的生长因子,包括bFGF,大多对皮肤伤口的纤维化、血管和再上皮化有介导和调控作用,可促进愈合.现将bFGF与创伤愈合的关系简要介绍如下:……
作者简介：陈佳(1979～),女(汉族),湖南长沙人,2002年湖南医学院毕业,现就读于湘雅三医院烧伤整形科硕士研究生.罗成群(1949～),男(汉族),湖南衡阳人,衡阳医学院毕业,主要从事创面修复与瘢痕预防的研究,科主任,教授,博士导师.
, http://www.100md.com
作者单位：陈佳(中南大学湘雅三医院整形烧伤科,湖南,长沙,410013)
罗成群(中南大学湘雅三医院整形烧伤科,湖南,长沙,410013)
参考文献：
[1]Vlodavsky I, Fuks Z, etal. Extracellular matrix- resident basic fibroblast growth factor: implication for the control of angiogenesis J Cell Biochem,1991,45(2):167.
[2]付小兵,现代创伤修复学[M].北京:人民军医出版社,1999:173～174.
[3]Cohen K. An overview of wound healing. In: Zieglcer TR, Pierce GF, Herndon DN, Eds. Growth factors and Wound Healing,Springer. New York, 1997: 3～7.
, 百拇医药
[4]戴方平,潘耀良,范清源,等.基因重组碱性成纤维细胞生长因子促进猪深Ⅱ度烧伤创面愈合的实验研究[J].中华整形烧伤外科杂志,1997,13(2):83～85.
[5]付小兵,沈祖尧,陈玉林,等.碱性成纤维细胞生长因子与创面修复--1024例多中心对照临床试验结果[J].中国修复重建外科杂志,1998,12(4);209～211.
[6]Smith PD, Polo M, etal. Efficacy of growth factors in the accelerated closure of interstices in explanted meshed human skin grafts. J Burn Care Rehabil.2000, 21 (1ptl): 5～9.
[7]Nissen NN, etal. Basic fibroblast growth factor mediates angiogenic activity in early surgical wounds. Surgery. 1996, 119 (4): 457～65.
, http://www.100md.com
[8]周志钢,何清濂,林子豪,等.碱性成纤维细胞生长因子作用血管内皮细胞后c-myc基因mRNA表达的实验研究[J].中华整形外科杂志,2000:299～301.
[9]程飚,付小兵、盛志勇,等.碱性成纤维细胞生长因子对肌成纤维细胞生长的作用及其对创面愈合的影响[J].中华医学杂志,2002:1187～1191.
[10]Boulfon AJM. Clinical promise of becaplermin gel: I. Diabetic foot ulcer. 8th Amual Meeting of the European. Tissue Rapair Society,1998, 37: 27～30.
[11]Okumura M, Okudat T, etal. Effect of basic fibroblast growth factor on wound healing in healing impaired animal models. Arzneimittelforschung, 1996, 46 (5): 547～51.
, 百拇医药
[12]Okumura M, etal Accelaration of wound healing in diabetic mice by basic fibrobblast growth factor. Biol Pharm Bull, 1996, 19 (4):530 ～ 5.
[13]Fu X, Shen Z. Healing of chronic cutaneous wounds by topical treatment with basic fibrolast growth factor. Chin Med J (Engl), 2002Mar; 115 (3): 331～5.
[14]王世岭,崔晓林,付小兵,等.重组人碱性成纤维细胞生长因子治疗烧伤及皮肤损伤的临床研究[J].中华创伤杂志,1999,6:196-199.
[15]Tan EM, Rouda S, etal. Aedic and basic fibroblast growth factors down- regulate collagen gene expression in keloid fibroblasts. Am J Pathol, 1993, 142 (2): 463.
[16]徐荣祥,萧摩,烧伤皮肤再生疗法与创面愈合的机制[J].中国烧伤创疡杂志,2003,15(4):253～261., 百拇医药
