【摘要】 目的 探讨颅内RDD的临床病理特点、诊断和鉴别诊断。方法 对1例颅内RDD进行组织形态学和免疫组织化学分析，并复习相关文献。结果 患者58岁，男性，MRI示左额脑膜瘤。组织学上，病变以硬膜为基础，见较多组织细胞，淋巴细胞和浆细胞浸润伴纤维化。可见淋巴细胞伸入组织细胞胞质内，免疫组化显示组织细胞表达S-100蛋白和CD68。结论 颅内RDD非常罕见，影像学常误诊为脑膜瘤，病理学特征为淋巴细胞、浆细胞进入组织细胞胞质内，免疫组化显示组织细胞表达S100和CD68强阳性，这是诊断RDD的重要依据。对颅内RDD行手术切除，预后良好。

    Gao Jin，Zhang Fulin，Li Zemin，et al.

    Department of Pathology，Jing An Distrist Central Hospital，Shanghai200040.

    【Abstract】 Objective To study thy clinical pathological characteristics of intracerebral Rosai-Dorfman disˉease and its diagnosis and differential diagnosis.Methods A case of intracerebral Rosai-Dorfman disease was studˉied by histopathological observation and immunohistochemical staining and review of related literature.Results A-58-year-old man was diagnosed by MRI as meningioma in left frontal lobe.Histologically it shows dural-based solitary masses where consist of variable numbers of histocytes ......