【摘要】 目的 了解米非司酮用于大鼠足月妊娠引产对新生鼠心肌组织的影响。方法 将孕鼠随机分为实验组和对照组，每组各5只，于孕第20天分别灌胃1ml麻油加米非司酮(11.5±1)mg和1ml麻油。均于分娩后24h内每窝取1只新生鼠断头处死取材，作透射电镜观察。结果 米非司酮组新生鼠心肌细胞间质水肿，核内异染色质比例增加，部分肌细胞胞质水肿，肌原纤维排列紊乱或断裂。线粒体明显肿胀、嵴断裂、糖原颗粒的沉积。间质毛细血管内皮细胞胞质水肿，线粒体肿胀，基底膜完整。结论 米非司酮用于大鼠足月妊娠引产可造成新生鼠心肌组织的缺氧性改变。

    Meng Ruilin，Wang Zineng，Gong Huafang，et al.

    Center for Disease Control and Prevention of Guangdong Province，Guangzhou510300.

    【Abstract】 Objective To investigate the influence of mifepristone used for full term pregnancy labor inducˉtion on the new borne rat’s myocardial tissue.Methods 10pregnant rats were randomly divided into two groups，conˉtrol group(n=5)with1ml sesame oil and experiment group(n=5)with1ml sesame oil+mifepristone11.5mg±1mg on the20 th day of pregnancy.24hrs after delivery of the maternal，the new borne rat’s(each from different materˉnal)myocardial tissue was acquired and prepared for transmission electron microscopic examination.Results In comˉparison with control groups ......