【摘要】 目的 探讨尿毒症患者血浆中分子物质(MMS)对大鼠心肌舒缩性的影响及改变的机制。方法 用凝胶层析法分离出MMS，经尾静脉注入大鼠体内，实验用左心室插管术，采集信号经换能器数字化后输入微机，应用CARDIO软件，分析注射MMS前后心肌舒缩性的改变。结果 注射MMS后，心室内压(peak)下降，室内压达峰值时间(peak time)推迟，室内压最大上升变化率(dp/dt max)减小，室内压下降最大变化率(-dp/dtmax)变慢，室内压下降最大变化速率所在时间(-dp/dt max time)延长，上述变化在注射MMS后1min即出现，持续12min左右开始恢复。结论 MMS可使心肌舒缩性减弱，说明MMS对大鼠心肌舒缩性具有抑制作用。

    Jiang Shujun，Wang Guilan，Gong Yongfeng

    Binzhou Medical College，Shandong Binzhou，256603.

    【Abstract】 Objective The effect of middle molecular substance(MMS)from the plasma of uraemia patients on rat’s myocardial contractility and its mechanism was investigated.Methods MMS were separated from the plasma of uraemia patients by gel-chromatograpy intubation was performed on the left ventricle of rats.The intraventricular pressure signal was sampled via a transducer ......