基金项目:广东省医学科研基金资助项目(编号:A2003286)

    【摘要】 目的 研究石菖蒲传统水煎剂对癫痫大鼠海马内兴奋性与抑制性氨基酸含量的影响，探讨其抗癫痫的可能机制。方法 采用传统水煎法得到石菖蒲水煎剂，脑室内注射海人酸(KA)建立大鼠癫痫模型，观察经水煎剂治疗后的癫痫大鼠海马氨基酸含量的变化。结果 经石菖蒲水煎剂7g/kg腹腔注射后的KA大鼠海马的γ-氨基丁酸(GABA)含量明显升高，谷氨(Glu)显著降低(P<0.01)。结论 石菖蒲水溶性成分可调节癫痫大鼠脑内的兴奋性与抑制性氨基酸的平衡，从而起到抗癫痫的作用。

    关键词 石菖蒲 海人 海马 GABA 癫痫 谷氨酸盐酯

    The changes of amino acid content in hippocampus of epileptic rats treated

    with decoction of acorus tatarinowii schott

    Chen Li，Liao Weiping，Sun Weiwen，et al.

    Department of Neurology，The First Affiliated Hospital of Guangzhou Medical College，Guangzhou，510120.

    【Abstract】 Objective To study the changes of excitatory and inhibitory amino acid content in hippocampus of epileptic rats treated with decoction of acorus tatarinowii schott，and explore the possible antiepiletic mechanism.Methods The decoction was made by traditional method ......