【摘要】 目的 应用美托洛尔治疗扩张型心肌病(DCM)目的在于减轻免疫介导的心肌损伤。方法 69例确诊为扩张型心肌病的患者，随机分组，治疗组在对照组常规治疗的基础上加用美托洛尔，观察治疗前后的心率(HR)、心胸比(C/T)、血压(BP)、左室腔舒张末内径(LVDd)、左室射血分数(LVEF)的变化及副作用。结果 (1)两组治疗后HR、心胸比与治疗前均有明显下降(P<0.01)，LVDd、LVEF差异有显著性(P<0.05);(2)无心衰组好转心衰组更显著;(3)副作用与药物剂量的增加有关。结论 应用美托洛尔对DCM的干预治疗，可以改善预后，特别是早期的扩张型心肌病。

    关键词 扩张型心肌病 美托洛尔 干预治疗

    The interfering treatment toward dilated cardiomyopathy with metoprolol

    Yu Po

    Shaogang Hospital，Guangdong512123.

    【Abstract】 Objective The application of metoprolol to treat dilated cardiomyopathy(DCM)is to alleviate the injury to myocardium by immuno media.Methods 69patients diagnosed as DCM are divided into two groups at random.Metoprolol is applied with treating group more than conventional treatment with control group.The side effects and the varieties of heart rate(HR)、cardiothoracic ratio(C/T)、blood pressure(BP)、left ventricular end diastolic diˉameter(LVDd)and left ventricular ejection fraction(LVEF)have been observed before and after the treatment.Reˉsults (1)The HR and C/T deceased evidently(P<0.01) ......