【摘要】 目的 研究牡荆子提取物(NCE)的保肝利用胆作用。方法 给动物灌胃(ig)给药，用四氯化碳(CCl 4 )、醋氨酚(AAP)及消旋乙硫氨酸(DL-En)建立急性肝损模型，测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)水平及肝中丙二醛(MDA)及甘油三酯(TG)含量;采用离体胆囊实验和胆管插管法，观察NCE对肝分泌胆汁的影响。结果 ig NCE后能明显降低由CCl 4 、AAP、DL-En引起的血清ALT、AST水平及肝组织MDA、TG含量;明显降低Ach、His等化学物质对豚鼠胆囊平滑肌的收缩性;增加大鼠胆流量。结论 NCE具有明显保肝、利胆作用。

    关键词 牡荆子提取物 保肝 利胆作用

    Experimental study on liver-protective and choleretic action of negundo chastetree extract(NCE)

    Luo Qifu，Zhou Dixian，Zhu Bingyang，et al.

    Department of pharmacology of Nanhua University，Hengyang421001.

    【Abstract】 Objective To study the liver-protection and choleretic action of negundo chastetree extract(NCE)in rats，mice and guinea pig.Methods NCE was administrated into the animal with liver injury induced by CCl 4 ，AAP and DL-En.ALT，AST level in serum and MDA，TG content in liver were examined.The isolated gallˉbladder smooth muscles model is used gathered the volume of bile by common bile duct intubation in different times.Compared the quantity of bile after given drugs.Results There were singnificant differences on model group compared with control group and NCE group(P<0.01).NCE could obviously reduce the level of ALT ......