【摘要】 目的 综述无机穴状化合物(NH 4 )18[NaSb 9 W 21 O 86 ]18- ，和Keggin型聚氧钨酸盐作为抗人类免疫缺陷病毒-1和抗癌药物的研究进展。方法 综述构效关系的研究与进展。结果与结论 展示无机穴状化合物和Keggin型聚氧钨酸盐在医药方面的应用前景。

    关键词 多金属氧酸盐 无机穴状聚锑钨氧酸盐 Keggin型聚钨氧酸盐 人类免疫缺陷病毒1 抗病毒活性 抗癌活性

    Characterization，anti-human immunodeficiency virus and anticancer activities of inorganic cryptate and Keggin-tpye polyoxotungstate anions

    Lin Xi

    College of Chemistry and Materials Science，Fujian Normal University，Fuzhou350007.

    【Abstract】 Objective To address the development of the inorganic cryptate(NH 4 ) 18 [NaSb 9 W 21 O 86 ] 18- (HPA-23)and Keggin-type polyoxotugstate as against HIV-1and anticancer agents.Methods The review on the researches and developments of structure-activity relationships.Results&Conclusion It has been shown，prospect in medicine for inorganic cryptate and Keggin-type polyoxotungstate anions.

    Key words polyoxemetalate inorganic crytate HPA-23 Keggin-type polyoxotugstate human immunodeˉficiency virus type antiviral activity anticancer activity

    杀灭引起爱滋病(AIDS)的人体免疫缺陷病毒(HIV)是摆在我们在面前的一大难题，药物化学家正致力于设计阻断HIV关键酶的药物，从而使感染停止。在不少国家恶性肿瘤已居死亡原因的首位 ......