【摘要】 目的 探讨连翘酯苷对四氯化碳肝毒性的保护作用。方法 ip连翘酯苷100～400mg/kg，连续5d。然后ip给予小鼠四氯化碳(10ml/kg)，18h后取血清测定丙氨酸氨基转换酶(ALT)酶活性为四氯化碳肝损伤的指标。结果 连翘酯苷100～400mg/kg，均可明显对抗四氯化碳引起的小鼠血液ALT活性上升。结论 连翘酯苷对四氯化碳肝损伤有明显的保护作用，其拮抗CCl 4 肝毒性的作用可能与其抗氧化能力有关。

    Lin Zhen，Wang Jindong，Chai Qiuyan

    Shanxi College of Biological Application Vocational Technology，Taiyuan030031.

    【Abstract】 Objective To investigate the protective effects of Forsythoside(FOS)on carbon tetrachloride(CCl 4 )-induced liver damage in mice.Methods Acute hepatic injury was produced by ip0.1%CCl 4 10ml/kg in mice.The biochemical indexes(ALT serum continuous)was measured.Results It showed that FOS could obviously inhibit the increase of ALT activity in serum.Conclusion FOS confers protection against the deterious effect of CCl 4 to mice liver ......