【摘要】 目的 研究预防性应用人参银杏复方制剂对缺氧24h复氧0、24、72h时段大鼠HDB部位ChAT表达的影响。方法 应用低压氧舱仿海拔8000m高空缺氧模型，采用免疫组织化学并结合图像分析等技术。结果 缺氧24h复氧0h组大鼠HDB部位ChAT相对含量较常氧对照组减少，复氧24h后减少更加明显，复氧72h后ChAT相对含量略有回升。预防性应用人参银杏复方制剂后ChAT相对含量在复氧0、24h时和复氧72h时均较缺氧复氧实验组相应时段增加。结论 预防性应用人参银杏复方制剂可阻止缺氧复氧后大鼠HDB部位ChAT含量的减少，对缺氧复氧后大学习记忆障碍起到改善作用。

    关键词 人参银杏复方制剂 缺氧复氧 斜角带核水平部 胆碱乙酰化酶 大鼠

    The effect of renshen ginkgo extract compound on the expression

    of chAT in HDB of rat following hypoxia&reoxygenation

    Zhang Zhijun，Zhou Mingming，Ni Hengjian，et al.

    Department of Neurobiology，Nantong Medical College，Nantong226001.

    【Abstract】 Objective To study the effect of ginseng ginkgo extract compound on the express of ChAT in HDB after hypoxia for24h followed by reoxygenation for0h，24h，72h.Methods The hypoxia models at a8000miter high level were established in hypobaric oxygen chamber ......