【摘要】 目的 探讨多囊卵巢(PCOS)药物治疗后血清褪黑素(MT)测定的意义。方法 通过测定PCOS患者治疗前后血清MT及其它性激素水平的变化，研究其相互关系。其中治疗前组29例，治疗组21例，对照组10例。结果 PCOS等生殖内分泌疾病的MT水平较高，均值为(77.5±57.6)mg/ml，经克罗米芬治疗3～6个月后，其浓度无明显变化，而其他激素则变化较大，差异有显著性(P<0.05)。结论 PCOS治疗后3～6个月内血清MT水平基本稳定可能是它的另一个基本特征，但这一特征是否随着PCOS症状的改善而减弱甚至消失，尚需进一步研究。

    Zhou Lixue，He Yingming，Wang Liang’an，et al.

    Department of Obstetrics and Gynecology，Affiliated the Second Hospital， Zhongshan University，Guangzhou510000.

    【Abstract】 Objective To probe into the level of serum melatonin(MT)after treatment of PCOS.Methods To study the relationship between the changes of MT and other sexual hormones in PCOS patients after treatment and PCOS according to detect these hormome.The pre-treatment group had29cases，treatment group21cases and control group10cases.Results MT levels(77.5±57.6)mg/ml of PCOS were higher than that of other endocrinologic diseases.The concentration of MT in blood serum did not change distinctly within3～6months after using Clomid.But other hormones changed obviously.Conclusion The level ofMT in serum did not changed distinctlywithin3～6months after using Cloˉmid may be a new characteristic of PCOS.It’s necessary to perform furthermore research to investigate whether the new characteristic will attenuat or disapper with the improvement of PCOS or not. ......