【摘要】 目的 体外静脉转流应用于原位肝移植术，观察血流动力学及激活全血凝固时间变化。方法 杂种猪40头，随机分为供体组和受体组，采用人工心肺机单泵，在非全身肝素化下，于实验猪原位肝移植术无肝期行门静脉、下腔静脉至上腔静脉的转流，测定术中血流动力学和激活全血凝固时间的指标。结果 术中血流动力学除在无肝期及开放后早期时间内有明显波动外，余无特殊变化，此外转流期部分肝素化，并不影响转流后凝血功能。体外静脉转流量达1000ml/min，整个过程血流动力学波动小，而静脉转流量小于500ml/min则术中血流动力学不能维持。结论 在原位肝移植过程中，良好的外静脉转流对维持血流动力学稳定有重要意义，转流后及时用鱼精蛋白中和肝素可促进凝血功能正常。

    Li Tiancheng，Qiang Yi

    Department of Cardiovascular Sugery，The first Affiliated Hospital of Lanzhou Medical College，Gansu730000

    【Abstract】 Objective To observe the changes of hemodynamic and Activeated Coagulation Time of Whole Blood(ACT)during liver transplantation under veno-venous bypass.Methods Pigs were randomly dlivided into donor and recipient groups.A veno-venous bypass from the portal vein and the inferior venscava to the superior venacava with the single centrifugal pump was used during the an-heptiC phase of porcine orhottopic liver fransp lineation.The profriles of the hemodynamic and ACT changes in a series of40pig orhotopic liver transplanted cases were obtained.Results It was shown that during the veno-venous by-passed enhepetic period ......