【摘要】 目的 通过对HBV前C区1896变异、中医证型、肝纤维化指标等的分析，了解1896位变异的中医证型分布特点，筛选相关预测因子。方法 将140例慢性乙型肝炎患者随机分为前C区变异阳性组和阴性组，通过指标的检测对各组进行比较分析。结果 前C区变异阳性组与阴性组证型分布有显著性差异，Logistic回归分析显示CD4 + 、IV.C、DNA的OR均大于1。结论 HBV-DNA定量测定、CD4 + 、IV.C数值可看作发生乙型肝炎病毒前C区1896点变异的危险因子;从中医学角度而言，辨证为湿热血瘀兼正虚的慢乙肝患者出现前C区变异的机率可能较高。

    Dai Min，Wang Yongze，Yan Gongzhi

    The Third Affiliated Hospital，Zhongshan University of Medical Science，Guangzhou510630.

    【Abstract】 Objective We design this research to analyze the Traditional Chinese Medicine(TCM)syndrome and diagnosis of western medicine in patients with precore1896site mutation;to observe the index of serum level of Hepatitis B virus(HBV)DNA，T lymphocytes and hepatic fibrosis index;and explore the TCM syndrome and pathoˉgenesis change;try to find the before hand factors of precore mutation.Methods 140patients with CHB were ranˉdomly enrolled in the study as the study group.70patients had precore mutation.Check the index of serum level of HBV-DNA ......