【摘要】 目的 观察益胃消增胶囊对慢性萎缩性胃炎(CAG)模型大鼠胃粘膜病理组织学的影响。方法 将78只Wistar雄性大鼠随机分为6组:正常对照组、模型组、自然恢复组、维酶素对照组、益胃消增胶囊低剂量组及益胃消增胶囊高剂量组。应用2%水杨酸溶液及150g/L、55℃热盐水灌胃、20mmol/L脱氧胆酸钠溶液自由饮用方法对正常对照组以外的其他各组大鼠进行造模60天，造模成功后，将模型组大鼠处死，留取胃粘膜标本待测，另五组大鼠施加相关因素30天后处死，同样留取胃粘膜标本，分别用光镜和电镜观察胃粘膜组织学方面的改变。结果 益胃消增胶囊治疗组大鼠胃粘膜炎症、萎缩、肠化等各项病理指标与模型组比较P均<0.01，不典型增生的改变与模型组比较P均<0.05，病理组织学改善明显。结论 益胃消增胶囊能够消除胃粘膜炎症，并能改善、甚至部分逆转CAG已经形成的萎缩、肠化及不典型增生等，这提示本方能有效治疗CAG，并能防止其癌变。

    关键词 慢性萎缩性胃炎 病理组织学 益胃消增胶囊

    The effect of YiWeiXiaoZeng Capsule on gastricmucosa pathological history in rats model of chronic atrophic gastritis

    Gong Zhangyue，Fan Ming，Gong Qimiao，et al.

    The First Affiliated Hospital of Heilongjiang University of TCM，Haerbin150040.

    【Abstract】 Objective To observe the effect of YiWeiXiaoZeng Capsule(YWC)on gastric mucosa pathologiˉcal histology in rats model of chronic atrophic gastritis.Methods Seventy eight male Wistar rats were randomly diˉvided into six groups:normal control group，model group，natural recovery group，WeiMeiSu control group，low-dose YWC group and high-dose YWC group.CAG model was established by synthetical method:salicylas and high-salt hot water and sodium deoxycholate we ......