【摘要】 目的 探讨TIMP-1在胃癌中的表达与肿瘤浸润、转移及预后的关系。方法采用免疫组织化学技术(SP法)对63例胃癌组织的TIMP-1进行检测，结合临床资料进行分析。结果 胃癌组织的TIMP-1的阳性表达率为52.4%(33/63)。TIMP-1的表达强度随着分化程度的升高而增加;在早癌组中表达良好，而在进展期癌组中表达差;在无淋巴结转移组中表达较有淋巴结转移组中表达好。结论 TIMP-1可作为判断胃癌恶性行为的重要生物学指标，亦是判断预后的重要指标。

    关键词 胃癌 浸润和肿瘤转移 基质金属蛋白酶抑制剂

    Expression of tissue inhibitor of metalloproteinases in human gastric cancer and its invasion and metastasis

    Zhao Hai

    General Hospital of Fushun Mineral Group，Liaoning113008.

    【Abstract】 Objective The aim of this study was to investigate the relationship between presence of TIMP-1and invasion，metastasis，prognosis of gastric cancer.Methods Sixty-three specimens of gastric cancer as control were assessed by

    immunohistological method(SP method).Results The rate of positive expressions of TIMP-1was52.4%(33/63).The more high expression of TIMP-1in gastric cancer，the more deeply staining of histologic clasˉsification;The expression of TIMP-1

    in early gastric carcinoma had strong staining ......