【摘要】 目的 探讨骨髓增生异常综合征(MDS)与免疫性疾病(ID)的相关性，治疗及预后情况。方法 对96例MDS患者的临床资料进行分析及随访观察。结果 96例MDS患者15例并发免疫性疾病，占15.6%;MDS并发免疫性疾病以类风湿关节炎(26.7%)、皮肤血管炎(20.0%)较多见;MDS并发免疫性疾病者较无免疫性疾病者其急变率虽不增加，但中位生存期明显缩短，部分MDS并发免疫性疾病者免疫抑制治疗可使其骨髓造血功能改善。结论 并发免疫性疾病是MDS预后不良的因素。免疫异常在部分MDS患者的发病机制中占有重要位置。

    关键词 骨髓增生异常综合征 免疫性疾病

     The relationship between myelodysplastic syndromes and immune disorders

    Li Junjun，Yan Jiayun，Ou Daming，et al.

    Department of Hematology，The First Affiliated Hospital，Nanhua University，Hengyang421001

    【Abstract】 Objective To explore the relationship between the myelodysplastic syndromes(MDS)and immune disorders(ID).Methods The clinical data of96MDS patients were reviewed.Results 15of96(15.6%)MDS paˉtients had IDs.The commonest ID associated withMDS was rheumatoid arthritis(26.7%)and intravascular inflammation of skin(20.0%).Compared with that in MDS patients without immune disorders the leukemic transformation rate was not increased in the MDS/ID but the median survival time was shorter in MDS/ID patients.The treatment of immunosupˉpressant was effective to the commonest ID associated withMDS.Conclusion MDS patients associated with immune disˉorders may be a bad factor for their prognosis.The abnormal immune has played an important role in the mechanism of part MDS patients. ......