【摘要】 目的 探讨温度、硫酸浓度对罗红霉素制剂溶出度测定结果的影响。方法 选用双因子交叉实验设计，采用紫外分光光度法测定，运用数理统计学方法对数据进行分析。结果 不同的温度和硫酸溶液浓度对罗红霉素溶液吸光度有显著影响(P<0.05);两者对吸光度的影响存在显著的交互作用(P<0.05)。不同厂家的硫酸试剂对罗红霉素制剂溶出度的测定结果也有影响。结论 罗红霉素制剂溶出度测定建议选用浓度为(75→100)的硫酸溶液，在60℃水浴中显色30min为宜。

    关键词 温度 硫酸 罗红霉素 溶出度

    The influence on the results of the dissolution determination of the roxithromycin preparation by the temperature and the concentration of sulphate acid solution

    Li Zhifu，Zhang Guohao，Li Yanli

    Zhuzhou Institute for Drug control of Hunan Province，Zhuzhou，412008.

    【Abstract】 Objective To study the influence on the results of the dissolution determination of the Roxˉithromycin preparation by the temperature and the concentration of sulphate acid solution.Methods Two-factors cross design of the experiments and the spectrophotometry were used ......