【摘要】 目的 用三氧化二砷(As 2 O 3 )及全反式维甲酸(RA)治疗急性早幼粒细胞白血病(APL)62例，进行临床疗效对比分析。方法 研究用As 2 O 3 方案(30例)和用RA方案(32例)治疗APL的缓解率，无病生存期及其毒副作用。结果 As 2 O 3 组、RA组的完全缓解率分别为80%及78.1%;两组缓解期及生存期差异亦无显著性(P>0.05)，但As 2 O 3 治疗剂量的毒副作用小，均为可逆性。结论 As 2 O 3 能诱导细胞凋亡，与RA无交叉耐药性，对治疗APL有良好疗效，且应用安全的一种诱导分化剂。

    关键词 三氧化二砷 全反式维甲酸 急性早幼粒细胞白血病

     【文献标识码】 A 【文章编号】 1680-6115(2004)07-0613-02

    The effects observation of treating APL with AS 2 O 3 and RA

    Zhang Xiong，Zhao Fujin，Gu Maoqun，et al.

    The People’s Hospital of Maoming City，Guangdong525000.

    【Abstract】 Objective Make a comparative analysis about AS 2 O 3 and RA’s clinical effects by using them to treat APL.Methods Study the APL’s relief rate，non-disease survival period after being treated with AS 2 O 3 scheme(30cases)or RA scheme(22cases)and their toxic and side reaction.Results The complete relief rate of AS 2 O 3 scheme and RA scheme were80%and78.1%respectively.There is no distinct difference between the relief period and survival period ......