【摘要】 目的 本实验旨在验证肝毒清颗粒对酒精性肝病合并内毒素血症的保护作用。方法 采用SD大鼠进行酒精灌胃制作酒精性肝损伤动物模型，观察肝毒清颗粒对酒精性肝损伤大鼠血浆内毒素(ET)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)及肝组织病理学指标的影响。结果 模型组ET、TNF-α及IL-6高于治疗组(P<0.05)，明显高于正常对照组(P<0.01);治疗组与对照组比较，差异无显著性(P>0.05);所有检测数据同肝组织的病理学变化相一致。结论 肝毒清颗粒有较好的防治酒精性肝损伤合并内毒素血症的作用。

    关键词 肝毒清颗粒 大鼠 肝损伤 内毒素血症

    The protective effect of Ganduqing granule on alcoholic liver injury and endotoxemia in rats

    Wei Mei，Liu Qiru，Wu Yuchuan，et al.

    Department of lntegrated Traditional and Western Medicine of Luzhou Medical College，Sichuan646000.

    【Abstract】 Objective To observe the protecitve effect of Ganduqing granule on alcoholic liver injury and enˉdotoxemia in rats.Methods The SD rat model of alcoholic liver injury was induced by intragastric infusion of alcohol orally and the levels of plasma endotoxin(ET)，tumour necrosis factor alpha(TNF-α)and interleuckin-6(IL-6)were measured and liver pathology was observed with light microscopy.Results The levels of ET，TNF-αand IL-6in the model group were higher than those in the Ganduqing granules group(P<0.05) ......