【摘要】 目的 调查5-羟色胺转运体基因中5-HTTLPR与5-HTTStin2多态位点在中国汉族人群中的多态性分布，比较这两个多态位点在种族间的差异，并且首次在中国汉族人群中对这两个多态位点与焦虑相关人格特质进行相关性研究。方法 利用PCR等方法在中国汉族人群中222个随机健康人对两个多态性位点进行了群体遗传学研究，并就这两个位点与焦虑相关人格特质(采用NEO量表)进行了相关分析。结果 5-HTTLPR多态信息含量为0.352;5-HTTStin2多态信息含量为0.153。等位片断频率在中国汉族人与美国黑种人及美国白种人、西欧人、土耳其人比较差异有显著性，而与日本人相似。这两个位点与焦虑人格特质相关分析未能得出阳性结论。结论 这两个多态位点在不同种族和人群中的分布有差异;相关分析结果不支持在中国对于5-HTTLPR、5-HTTStin2这两个多态位点在不同种族和人群中的分布有差异;相关分析结果不支持在中国汉族人群中这两个多态位点与焦虑相关人格特质有关。

    关键词 5-羟色胺转运体 多态性 焦虑 人格 NEO人格量表

    Study of the association between the serotonin transporter gene polymorphism and anxiety-related personality traits in Chinese

    Xu Lanping，Huang Lijia，Liu Jingzhong，et al.

    Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences，Biejing100020.

    【Abstract】 Objective To investigate the allele frequency of5-HTTLPR，5-HTTStin2genes compared it with other populations，and find an association study in Han Chinese.Methods DNA were extracted from peripheral blood samples of222unrelated healthy Han Chinese individuals.Genotype were detemined by PCR.An association beˉtween the two polymorphism traits was studied in a ample of148healthy Han Chinese subjects.Results (1)For5-HTTLPR ......