【摘要】 目的 探讨儿童哮喘与IgE高亲和力受体β链基因多态性的关系。方法 采用ELISA法检测血清总IgE水平。应用ARMS-PCR方法检测IgE高亲和力受体β链基因多态性。统计方法采用χ 2 和t或U检验。结果 (1)哮喘组血清总IgE水平显著升高，与对照组比较差异有显著性。(2)FcεRI-βI181L突变等位基因频率，哮喘组显著高于对照组，差异有显著性，OR=2.00(95%CI1.10～3.11);哮喘组和正常组均未检测到FcεRI-βV183L突变;Log 10 IgE Titer值，IgE I181L突变型与未突变型比较差异均无显著性。结论 小儿哮喘是多基因遗传病，FcεRI-βI181L突变可能是我国长春地区汉族儿童哮喘的易感基因。

    关键词 支气管哮喘 IgE高亲和力受体 基因多态性 儿童

    Associated study of high affinity receptor for immunoglobulin E gene

    polymorphisms with asthma on children in Changchun

    Zhao Fangxing，Wang Zhenhua，Zhao Kaishu，et al.

    Emergency ward，Children’s Hospital of Changchun，Changchun130061.

    【Abstract】 Objective To investigate the association of FcεRI-βgene polymorphisms with asthma in Changchun children.Methods ELISA，ARMS-PCR methods were developed in the study.Results The levels of serum total IgE in asthmatic subjects were higher than those of controls.The allete frequencise of FcεRI-βI181L gene mutaion in asthmatic individuals was higher than those of group，without gene mutation.OR value was2.00(95%CI1.10～3.11)，FcεRI-βV183L gene mutation were absent in asthmatic individuals and controls.Log 10 IgE Titer values were not different in asthmatic individuals with FcεRI-βI181L from those without gene mutation.Conclusion Bronchial asthma is polygenetic disorder ......