【摘要】 目的 探讨多菌型麻风联合化疗(MDT)后麻风菌的活性及复发的关系。方法 用荧光素乙酰乙酸盐(FDA)和溴乙啡啶(EB)双荧光染色法检测麻风菌的活性，抗酸染色(AFB)记录细菌指数(BI)及形态指数(MI)。结果 检测多菌型麻风患者共29例，其中初治MDT期满22例，复发MDT期满7例，共检出绿染菌4例。抗酸染色查菌阳性者中复发患者平均BI高于初治患者平均BI，两者间差异有非常显著性(P<0.01)。复发未治患者5例，AFB、FDA/EB染色均阳性，平均绿染菌49.6%。结论 MDT期满后FDA/EB染色查到绿染菌或者抗酸染色BI较高者，应适当延长MDT治疗时间或用其它替代疗法治疗直至查菌阴转，以防复发。

    关键词 联合化疗 麻风菌 活性 复发

    Study on viability of mycobacterium leprae after multidrug therapy

    in multibacillary leprosy and relapse

    Huang Jinmei，Zheng Heping，Pan Huiqing，et al.

    Guangdong Provincial Centers for Skin Diseases and STDs Control and Prevention，Guangzhou510500

    【Abstract】 Objective To investigate viability of M.leprae after multidrug therapy(MDT)in multibacillary lepˉrosy and relapse.Methods Viability of M.leprae was defected with fluorescent staining procedure(FDA/EB)and AFB for bacteria index(BI)and modality index.Results A total of29cases multibacillary leprosy patients ......