【摘要】 目的 在其它肿瘤的研究中发现单核细胞趋化蛋白-1(monocyte chemoattractant protein-1，MCP-1)参与了肿瘤的血管生成，本研究探讨口腔(鳞状细胞癌，简称鳞癌)中MCP-1表达与肿瘤血管生成的关系。 方法 应用免疫组化方法检测41例口腔鳞癌和10例正常口腔黏膜MCP-1和CD34的表达，光镜下进行MCP-1表达的分级和微血管的计数。 结果 口腔鳞癌中MCP-1的表达和微血管计数较正常口腔黏膜均增加(P<0.01)，在鳞癌中随MCP-1表达的增加，微血管计数增加(P<0.01)。 结论 MCP-1在口腔鳞癌中参与了肿瘤的血管生成，但其具体机制和在临床中的意义还需进一步的研究。

    关键词 口腔鳞状细胞癌 肿瘤血管生成 单核细胞趋化蛋白-1

    The correlation between expression of monocyte chemoattractant protein-1 and angiogenesis in human oral squamous cell cancer

    Song Yufeng，Yang Jianbin，Feng Hongchao

    Department of Oral Surgery，The Affiliated Hospital of Guiyang Medical College，Guiyang550004

    【Abstract】 Objective Many investigations have showed that monocyte chemoattractant protein-1(MCP-1)participated in tumor angiogenesis.To study the correlation between the expression of MCP-1and angiogenesis by ex-ploring the expression of MCP-1and angiogenesis in oral squamous cell cancer(OSCC)and oral normal tissue.Methods The expression of MCP-1and microvessel counts were detected by immunohistochemical methods in paraffin section of41OSCC and10normal oral tissues.Results The expression of MCP-1in OSCC group was sig-nificantly higher than that in normal group(P<0.01);Microvessel counts in OSCC group was also higher than that in normal group(P<0.01).The expression of MCP-1was significantly correlated with the microvessal counts(P<0.01).Conclusion MCP-1plays a crucial role in angiogenesis of OSCC ......