【摘要】 目的 P16和BCL—2在53例在肠癌中的表达，了解该基因与大肠癌生物学行为的关系。 方法 采用LABC免疫组化方法观察，P16基因，BCL—2基因产物在53例大肠癌组织中的表达情况。 结果 53例大肠癌中，P16阳性34例，BCL—2阳性33例，且P16随分化程度降低，阳性率降低，高分化与低分化癌差别有显著意义。BCL—2随分化程度降低而阳性率升高，低分化癌与高分化癌及粘液癌差别有显著意义。 结论 本研究表明P16，BCL—2表达与大肠癌的分化程度相关。

    【关键词】 大肠癌 P16 BCL-2 免疫组化

    The study on expressions of P16，BCL-2genes in colorectal carcinoma

    Kang Xiaoxu

    NO.4People's Hospital of Panjin，Liaoning，124000.

    【Abstract】 Objective To examine the expressions of P16and BCL-2genes in53cases of colorectal carci-noma determined the relationship between the genes and colorectal carcinoma.Methods The expression of P16and BCL-2in53cases colorectal carcinoma was detected by SABC immunohistochemical method.Results In53cases colorectal carcinoma，P16was positive in34and BCL-2was33.The P16positive rates were significantly lower in poorly differentiated.Expressions of P16in well differentiated colorectal carcinoma were significantly different from poorly.The BCL-2positive rates were significantly higher.In poorly differentiated，expressions of BCL-2in well or mucus colorectal carcinoma were significantly different from poorly differentiated colorectal carcinomas.Conclusion Our results showed that the expression of P16and BCL-2was closely related to differentiation. ......