【摘要】 目的 探讨栝蒌薤白半夏汤(GXBD)对心肌缺血大鼠内源性血管活性因子及心肌病理形态学的影响。 方法 通过结扎大鼠冠状动脉左前降支造成急性心肌缺血模型，用不同剂量的GXBD处理，造模后1h采血测血浆内皮素(ET)和血清一氧化氮(NO)，并进行心肌病理形态学观察。 结果 急性心肌缺血模型组ET明显升高，NO明显下降，GXBD可以对抗心肌缺血大鼠ET的升高，提高NO的水平，与模型组比较差异有显著性(P<0.01或P<0.05);GXBD可以有效的保护缺血心肌纤维结构和功能，与模型组比较差异有显著性(P<0.01或P<0.05)。 结论 GXBD能改善心肌缺血大鼠的内皮功能及心肌损伤，并能调节ET和NO分泌的失衡。

    关键词 栝蒌薤白半夏汤 急性心肌缺血大鼠 内源性血管活性因子 心肌病理形态学

    Influence of Gualou Xiebai Banxia Decoction on the endothelial vaso-active factors and myocardial pathomorphology of acute myocardial ischemia rats

    Zhang Bingtian，Li Xinhui，Du Jianfang，et al.

    Hunan College of Traditional Chinese Medicine，Changsha410007.

    【Abstract】 Objective To investigate the effects of Gualou Xiebai Banxia Decoction(GXBD)on the endothe-lial vaso-active factors and myocardial pathomorphology of acute myocardial ischemia rats.Methods The left anteri-or descending coronary arterywas ligated to make a model of acute ischemic myocardium.Blood would be collected for assaying the plasma endothelin(ET)and the nitric oxide(NO)，and myocardial pathomorphological examination would be preceded after the myocardial ischemia models being set up for one hours.Results GXBD could decrease not only the levels of plasma ET and increase the concentration of serum NO ......