【摘要】 目的 探讨脑梗死后脑心损伤的自由基病理机制及针刺的拮抗效应。 方法 以一侧大脑中动脉阻断大鼠(MCAo)为脑梗死实验模型，检测三组(正常组、模型组、针刺组)大鼠四个时相(模型组与针刺组分为3h、6h、24h、48h四个时相)脑心组织及血液超氧化物歧化酶(SOD)、丙二醛(MDA)含量。SOD用放射免疫分析法检测，MDA用硫代巴比妥酸比色法测定。 结果 模型组大鼠脑心组织及血液SOD在3h、6h、24h、48h四个时相均较正常组显著下降(P<0.05或P<0.01)，MDA含量在3h、6h、24h、48h四个时相均较正常组显著升高(P<0.05或P<0.01)。针刺组与模型组比较，各个时相大鼠脑心组织及血液SOD明显升高，MDA明显下降(P<0.05或P<0.01)。 结论 脑梗死后自由基参与了脑心损伤病理过程，针刺人中、内关穴能有效拮抗自由基的损伤。

    关键词 脑梗死 大鼠 脑心组织 针刺 丙二醛 超氧化物歧化酶

    Influence of acupuncture on contents of SOD and MDA in cerebro-cardiac tissue and blood in cerebral infarct rats

    Meng Zhihong，Du Yuanhao

    The First Affiliated Hospital of Tianjin University of TCM，Tianjin300193.

    【Abstract】 Objective To discuss free radical pathologic mechanism and antagonistic effect of acupuncture on organ of brain and heart after cerebral infarction.Methods Animal model was established byMCAO，measuring con-tent of SOD，MDA in Cerebro-cardiac tissue and blood on normal group，model group and acupuncture group(on MCAO group and acupuncture group at3h，6h，24h and48h).SOD was measured by radio-immunity method ......