【摘要】 目的 通过选择三种肿瘤标记物，应用一种相对简单、可靠的判定方法，以提高临床诊断良恶性胸腔积液的符合率。 方法 选择经病理证实的良恶性胸液各30例，用放射免疫分析法检测其CEA、CYFRA21-1、β 2 -MG水平，应用判别式法对联检结果进行良恶性的判定。 结果 (1)3种标志物浓度在良、恶性组中有显著差别，P<0.01。(2)3种标志物的敏感度、特异度、准确度分别为CEA(80.0%、93.3%、86.6%)、CYFRA21-1(80.0%、86.7%、83.3%)、β 2 -MG(83.3%、83.3%、83.3%)。(3)将三种标记物代入判别式，得出敏感度、特异度、准确度为86.7%、96.7%、91.7%。 结论 以上三种标记物联合检测，明显提高了良恶性胸腔积液诊断的准确率。

    关键词 胸腔积液 敏感度 特异度 准确度 CEA CYFRA21-1 β 2 -MG

    The utility value of three markers in differentiating benign and malignant pleural effusion

    Chen Yu，Chen Xing，Zhao Lishuang

    Department of Respiration，Affiliated Hospital of Chengde Medical College，Chengde067000.

    【Abstract】 Objective To choose relative easy and reliable method of tumor markers in order to increase ac-curacy of clinic diagnosis.Methods Radioimmunoassaywas used to detect the levels of CEA，CYFRA21-1，β 2 -MG of pleural effusion in30malignant and30benign patients.The discriminant was used to evaluate the combined re-sults.Results (1)Statistical differences of the three markers were found in benign and malignant pleural effusion(P<0.01).(2)Sensitivity ......