【摘要】 目的 探讨缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)在膀胱肿瘤发生、发展中的作用。 方法 采用免疫组织化学染色方法对62例原发膀胱移行细胞癌及8例正常膀胱组织中HIF-1α和VEGF的表达进行检测，回顾性分析HIF-1α和VEGF表达与肿瘤病理分级、临床分期、复发的关系。 结果 膀胱癌组织中HIF-1α和VEGF的阳性表达率分别为46.8%和56.5%，而8例正常膀胱粘膜组织HIF-1α和VEGF表达均为阴性。HIF-1α和VEGF表达与膀胱肿瘤病理分级、临床分期、复发密切相关。同时本次试验结果显示，HIF-1α表达和VEGF表达呈显著正相关。 结论 HIF-1α和VEGF表达对膀胱癌生物学行为有重要影响，同时检测HIF-1α和VEGF的表达情况，对于判定膀胱癌复发、转移和预后更有价值。

    【关键词】 膀胱肿瘤 HIF-1α VEGF 免疫组化

    An investigation on relation of HIF-1αand VEGF expression with the biological behavior of bladder cancer

    Wang Xing，Sun Lanfen

    Department of Pathology，The Third Municipal Hospital of Tianjin，Tianjin300250.

    【Abstract】 Objective To evaluate expression of hypoxia-inducible factor-1α(HIF-1α)and its relation to vascular endothelial growth factor(VEGF)in bladder cancer.Methods HIF-1αand VEGF were examined with immunohistochemical stain method in68cases of transitional-cell carcinoma(TCC)and8subjects of normal bladder mucosa.Results Positive rates of HIF-1αand VEGF were46.8%and56.5%respectively in TCC cases and no expression was observed in normal specimens.The HIF-1αexpression were both significantly related with VEGF ......