【摘要】 目的 探讨氯胺酮(Ketamine，Ket)对失血性休克家兔休克前后血浆肿瘤坏死因子(TNF-α)、白介素-1(IL-1)、血浆丙二醛(MDA)含量和血浆总抗氧化能力(T-AOC)的影响，探讨氯胺酮在失血性休克中的作用及其机制。 方法 家兔40只，随机分为4组:对照组、休克组(S组)，氯胺酮1、2组(Ket 1 、Ket 2 组)。建立失血性休克模型。于放血前、放血后30min、1h、4h、8h取静脉血5ml。测定肿瘤坏死因子、白介素-1、血浆丙二醛浓度和总抗氧化能力。 结果 氯胺酮能明显降低失血性休克家兔血浆TNF、IL-1、MDA的升高(P<0.05)，升高失血性休克家兔血总抗氧化能力(P<0.05)。 结论 氯胺酮在失血性休克家兔的麻醉中具有一定的对抗休克细胞因子作用和抗自由基作用。

    关键词 氯胺酮 肿瘤坏死因子 白介素-1 丙二醛 总抗氧化能力 休克 失血性 家兔

    The effects of ketamine on the hemorrhagic shock in rabbits

    Su Aizhong，Liu Zaiying

    The Affiliated Hongqi Hospital，Mu Danjiang Medical College，Helongjiang157011.

    【Abstract】 Objective To observe and explore the treatment and mechanism of ketamine on hemorrhagic shock.Methods Forty rabbits were divided randomly into four groups:contrast group，shock group，Ket1group，Ket2group.To estimate the level of tumor necrosis factor(TNF)，interleukin-1(IL-1)，the level of malonate aldehyde(MDA)，the activity of total anti-oxidize capcity(T-AOC)in plasma in hemorrhagic shock rabbits.Re-sults Ketamine can obviously decrease the TNF，IL-1level of plasma in hemorrhagic shock rabbits(P<0.05).Ketamine can remarkably decrease MDA level of plasma in hemorrhagic shock rabbits(P<0.05).Ketamine can ob-viously increase T-AO activity of plasma in hemorrhagic shock rabbits(P<0.05).Conclusion Ketamine has fuction of anti-cytokine and anti-oxygen free radical on hemorrhagic shock. ......