【摘要】 目的 研究雌二醇(Estradiol，E)对大鼠腹腔巨噬细胞的免疫作用机制。 方法 以大鼠腹腔巨噬细胞为对象，采用吞噬中性红法及MTT法，观察不同剂量、不同时间雌激素处理后腹腔巨噬细胞的活性及吞噬功能的变化。 结果 剂量为10 -4 、10 -6 可引起腹腔巨噬细胞吞噬功能抑制，该作用在E处理后的4h、8h、20h均明显，随时间延长，作用增加。剂量10 -8 可增强吞噬功能。 结论 E具有免疫增强和免疫抑制双重功效，并随时间、剂量大小有变化。

    关键词 雌二醇 腹腔巨噬细胞 免疫抑制 免疫增强

    Effects of estradiol on immunocompetence of peritoneal macrophages of rat in vitro

    Yuan Wendan，Yang Fang，Chen Jinrong

    Department of Pathophysiology，Binzhou Medical College，Shandong256603.

    【Abstract】 Objective To investigate the immunological function of estradiol in vitro.Methods The prolif-erative ability of peritoneal macrophage was determined byMTT;The phagocytosis of rat peritoneal macrophages was e-valuated by neatral red method.Results E could not only obviously decrease the macrophage phagocytosis，but also decrease the proliferative ability induced by10 -4 E and10 -6 E.10 -8 E could increase immunocompetence of peritoneal macrophages.Conclusion Estradiol have the ability to regulate up or down the immunity.Effects are determined by time and dose. ......