【摘要】 目的 探讨高尿酸血症肾病的临床特征，提高对本病的认识。 方法 对1995～2003年住院的42例原发性高尿酸血症肾病进行临床分析。 结果 其占同期原发性痛风的75%，伴有关节损害者占81%。据BUN、Scr值，将患者分为非肾衰组与肾衰组。肾衰组合并高血压者显著高于非肾衰组;两组尿渗透压与血渗透压比值几乎均<1.5;肾衰组血尿酸与血肌酐>2.5的仅占50%，尿酸排泄量肾衰组较非肾衰组显著减少。 结论 提示高尿酸血症性肾病多数伴有关节炎，肾小管功能损害出现在肾小球功能损害之前，肾衰时不能简单地根据血尿酸与血肌酐比值判断有无高尿酸血症肾病。

    关键词 高尿酸血症 肾损害 关节炎

    【Abstract】 Objective To study the clinical characteristic of chronic uric acid nephropathy.Methods We investigated42cases of chronic uric acid nephropathy on patients hospitalized between1995and2003.Results It is about75%of the concurring gout，and81%of them were accompanied with arthritis.The patients were divided into renal failure group and non-renal failure group according to their blood uric nitrogen and serum creatinine parame-ters.While the both groups had similar uric osmotic pressure ratios(<1.5) ......