当前位置: 首页 > 医疗版 > 疾病专题 > 肾脏内科 > 肾病综合征 > 肾淀粉样变
编号:10580744
肾淀粉样变的电镜观察
http://www.100md.com 《中华医学研究杂志》 2005年第3期
肾淀粉,肾,淀粉样变性,电镜,超微结构,诊断,1材料与方法,2结果,3讨论,参考文献
     【摘要】 目的 探讨肾淀粉样变(amyloidsis,AL)的超微结构特点及电镜在其诊断中的作用。 方法 对我室近两年来接收的肾活检病例的电镜资料进行系统的回顾,疑为肾AL的病例加做刚果红染色。 结果 6例肾AL均以中老年为主,临床主要表现为肾病综合征。电镜下肾小球系膜区轻度或未见增生。6例患者均可在系膜区发现节段性的淀粉样纤维分布,纤维直径8~10nm。束状淀粉纤维可在肾小球基底膜(GBM)外侧沉积形成“钉”状突起结构,突起可呈节段分布或融合成片。刚果红染色均阳性。 结论 当电镜下发现肾小球系膜区及/或GBM淀粉样纤维沉积(尤其GBM外侧有淀粉沉积)时,结合临床表现,应高度怀疑淀粉样变,此时应加做光镜刚果红染色进一步确诊。

    关键词 肾 淀粉样变性 电镜 超微结构 诊断

    Electron microscopic observation of the renal amyloidosis

    Wu Qiang,Wang Chaojie,Chen Wenfang,et al.

    Lab of Electron Microscopy,Zhong-Shan Medical College,Sun Yat-sen University,Guangzhou510080.

    【Abstract】 Objective To investigate the ultrastructural feature of renal amyloidosis(AL)and the role of electron microscopy(EM)in the diagnosis of this disease.Methods Renal biopsy specimens collected by our labora-tory in the past two years were studied by EM.The cases supposed to be affected by amyloidosis in preliminary diag-nosis were stained with Congo-red.Results Six cases were selected.All of the patients are of middle age or aged-ness and are suffered from nephrotic syndrome.Electronic microscopy examination showed normal or mild expanded mesangium.But in all cases ......

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