【摘要】 目的 观察经保护处理后的辅酶A口服制剂经口给药对大鼠及家兔食饵性高脂血症的作用。 方法 采用雄性SD大鼠及雄性新西兰白兔以高脂饮食制备高脂血症模型，高脂饮食同时每日经口给予高中低3个剂量的辅酶A口服剂，对照采用辅酶A前体药泛硫乙胺、辅酶A口服剂的保护剂、辅酶A原药经口给药，以及注射用辅酶A肌肉注射。给药前后取血测定血总胆固醇、甘油三酯、低密度脂蛋白胆固醇及高密度脂蛋白胆固醇水平。 结果 辅酶A口服剂可以减轻大鼠及家兔食饵性高脂血症，减轻高脂饮食诱发的总胆固醇及低密度脂蛋白胆固醇的升高程度，大剂量辅酶A尚可降低家兔甘油三酯水平，且降脂作用呈剂量依赖性。辅酶A原药未见明显的降脂作用。 结论 辅酶A经保护处理后的口服制剂可以减轻高脂饮食诱发的高脂血症。

    关键词 高脂血症 辅酶A 大鼠 家兔

    Effects of an oral preparation of coenzyme A on food-induced hyperlipidemia in rats and rabbits

    Dong Na，Pan Jingwei，Zhang Da，et al.

    Department of Internal Medicine，Changhai Hospital，Second Military Medical University，Shanghai200433.

    【Abstract】 Objective To evaluate the effects of an oral preparation of coenzyme A(CoA)hyperlipidemia in rats and rabbits fed on high-lipid food.Methods Normal rats and rabbits were fed high-lipid food and oral CoA was administered intragastrically for2weeks.Results Oral CoA reduced total cholesterol and low density lipoprotein cholesterol dose dependently in rats and rabbits.Large dose of CoA also reduced triglyceride in rabbits.Conclusion The oral preparation of CoA could ameliorate hyperlipidemia in rats and rabbits. ......