【摘要】 目的 探讨C-反应蛋白(CRP)与原发性高血压(EH)的关系。方法 测定696例EH患者血清CRP浓度、甘油三酯浓度、总胆固醇浓度、极低密度脂蛋白浓度及血糖浓度等生化指标，并与613例对照组(健康者)比较，分析CRP与EH及其危险因素的关系。结果 高血压组、正常血压组血清CRP浓度分别为(1.91±1.85)mg/ml和(0.70±0.6)mg/ml(P<0.001)，CRP浓度随着血压级别的增加而增加，经过多元逐步回归分析，在排除高血压的其它危险因素影响后，CRP仍与EH呈正相关(P<0.0001)。结论 CRP浓度与EH呈正相关，炎症反应参与了EH的发生、发展。

    Gao Wenjing，Hao Bing，Wu Shouling，et al.

    Department of Cardiology of Affiliated Hospital of kailuan Company Ltd，Hebei Tangshan063000.

    【Abstract】 Objective To investigate the relationship between serum C-reactive protein(CRP)concentration and essential hypertension(EH).Methods The serum CRP concentration，triglyceride concentration，total cholesˉterol concentration，VLDL cholesterol concentration and glucose concentration were measured in696patients with EH，and were compared with those of the normal control group(n=613).To analyze the relationship between serum CRP level and EH as well as it’s risk factors.Results The serum CRP concentration were(1.91±1.85)mg/ml and(0

    .70±0.67)mg/ml in hypertensive group and normal control group respectively(P<0.001).The serum CRP concenˉtration rises with the blood pressure level.Multivariate regression analysis revealed that EH was associated with serum CRP concentration except for the other risk factors of EH(P<0.0001).Conclusion sorum CR conantration is asˉsociated with EH.Inflammatory response play an important role in the pathogenesis of EH. ......