名称：清瘟败毒饮对系统性红斑狼疮患者雷诺氏现象疗效之研究

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     主持人：张恒鸿 雷诺氏现象为系统性红斑狼疮患者常见之症，以往之研究报告显示：本症患者肢端血流有减少现象。依据传统中医学理，此多属「热厥」范畴，宜以清热凉血药物治疗。本研究在门诊筛选系统性红斑狼疮患者94名，先依雷诺氏现象之有无，分为两组，比较其末梢血流灌流量有无差异。其次将其中并见雷诺氏现象患者25名，依医界公认之治疗方法给予西药，症状稳定后，维持在最低剂量，并随机分为二组，实验组给予清瘟败毒饮浓缩药粉每次4公克，对照组给予安慰剂，一日三次，持续服药8周。服药前后各组均以雷射血流测定仪观测右手中指掌侧远程指节皮下血流，记录其平均血流灌流量，并以无母数分析两组服药前后之差异。 研究结果显示：系统性红斑狼疮并见雷诺氏现象患者基准点血流灌流量高于无雷诺氏现象患者(p=0.0054)，0分钟与7分钟之回复率则低于系统性红斑狼疮无雷诺氏现象患者(p=0.0116及0.0136)。实验组服药8周后，基准点血流灌流量下降(p=0.033)，血流回复率无明显改变；对照组则两者皆无显著差异。 系统性红斑狼疮并见雷诺氏现象患者基准点血流灌流量高于系统性红斑狼疮无雷诺氏现象患者，回复率则低于后者。清瘟败毒饮能降低系统性红斑狼疮并见雷诺氏现象患者之末梢血流灌流量，对回复率则无影响。 关键词：清瘟败毒饮、雷诺氏现象、系统性红斑狼疮
, 百拇医药
    Code Number:CCMP86-RD-003 Title:The

    therapeutic effects of Qing-wen-bai-du-yin on Raynaud′s phenomenon in patients with systemic lupus erythematosus Orgazination: China Medical College Auyhor:Hen-Hong Chang Raynaud′s phenomenon (RP) has been reported in 10-44% of the patients with systemic lupus erythematosus (SLE). The pathogenetic mechanism of SLE presenting with RP is compatible with "heat reversal" in Chinese medicine. According to the principle of classic Chinese medicine, heat reversal should be treated with "qing-wen-bai-du-yin(QW)" a Chinese herb prescription. We proceeded to carry out a double-blind case-controlled study of QW in SLE patients with RP. Ninty-four outpatients with SLE regularly treated with western medicine were selected. Laser Doppler flowmetry (LDF) were performed on them. Among them 25 patients with SLE presenting RP were randomly allocated to two groups. Thirteen patients took QW orally, 12g a day for 8 weeks, and 12 patients were given a placebo. Finger cooling test was applied to induce RP during the examination. Quantitative analysis of the blood perfusion on the volar fingertip of right middle finger was performed before and after treatment. The results showed that the baseline perfusion of the SLE patients with RP was higher than the SLE patients without RP (p=0.0054). The recovery ratios of the SLE patients with RP at 0 minute and 7 minute were lower than those without RP(p=0.0116 and 0.0136 respectively). The baseline perfusion of the cases decreased after treatment(p=0.033), but the recovery ratio of perfusion did not change significantly. The controls made no significant differences neither in baseline perfusion nor in recovery ratio of perfusion. There were differences between the SLE patients with RP and those without RP in peripheral perfusion. QW could reduce the perfusion of the SLE patients with RP, but it could not affect the recovery ratio of perfusion. keywords: Qing-wen-bai-du-yin, Raynaud′s phenomenon, Systemic lupus erythematosus, 百拇医药

    百拇医药网 http://www.100md.com/html/DirDu/2005/05/21/56/90/22.htm