【摘要】 目的 用绞股蓝总皂苷作为免疫增强剂治疗免疫低下小鼠模型，通过碳粒廓清实验观察非特异性免疫功能的变化，探讨绞股蓝总皂苷免疫增强的药理作用，观察剂量效果关系。 方法 小鼠随机分为6组，模型组皮下注射环磷酰胺40mg/kg，制造免疫低下模型，与各对照组和药物高、中、低剂量组分别做碳粒廓清实验，观察各组非特异性免疫功能变化。 结果 模型小鼠廓清指数明显下降，阳性对照组、绞股蓝高、中剂量组非特异性免疫功能指标明显增强。作用强度相似。绞股蓝总皂苷的作用呈剂量依赖性。 结论 以较低剂量环磷酰胺成功造成小鼠免疫低下模型。绞股蓝总皂苷能非常明显地增强非特异性免疫功能，作用呈剂量依赖性。最高剂量推荐200～400mg/kg。

    关键词 绞股蓝总皂苷 免疫学 NIH小鼠

    Effects of Gypenosides on the immune deficit mouse's non-specific immunological function

    Zhou Li，Ye Kaihe，Ren Xianda

    Department of Respiratory，Guangzhou TCM Hospital，Guangzhou510130.

    【Abstract】 Objective The Gypenosides is used as an immune enhancer to cure the immune deficit mouse and observe non-specific immunological function by carbon clear test.The pharmacological funtion of immune enhancer of Gypenosides is evaluated and the dose-effect relationship is discussed.Methods All of the mice were administered with CTX and then were divided into six groups:control group、model group、negative control group、high dose group、middle dose group、lower dose group.Respectively ......