【摘要】 目的 研究四逆散对原发性胆管结石患者术后T管引流胆汁成分的影响，探讨四逆散防治胆管结石的机制，深化对经典方的研究，拓宽其应用范围。 方法 33例原发性胆管结石患者术中置T管引流，随机分为两组，服药组和空白对照组，服药组于术后第5天胆汁肝肠循环恢复后服药。两组患者均于服药前1天及服药后第1、3、5天留取胆汁，测定胆汁中胆汁酸、胆红素、胆固醇、钙离子、免疫球蛋白(IgA，IgG)浓度。 结果 服药后无不良反应，服药前后胆汁色质变化不明显。服药前两组间各指标差异无显著性;服药后1天两组间各指标差异无显著性(P>0.05);服药后3天两组间比较胆汁酸差异有显著性(P<0.05);服药后5天两组间比较胆汁酸(P<0.01)、间接胆红素(P<0.05)、免疫球蛋白IgG(P<0.05)。 结论 四逆散疏肝理气，通过对胆汁酸、间接胆红素及免疫球蛋白IgG的影响，对原发性胆管结石中的胆色素结石有一定的预防作用。

    【关键词】 四逆散 原发性胆管结石 胆汁成分

    The study of SI-NI-SAN in effect of bile component on postoper-ational

    patients of primary bile duct stone Gao Yingfei，Chen Xianxiang，Yu Feng，et al.

    Department of Hubei Traditional Chinese Medical College，Wuhan，Hubei430061.

    【Abstract】 Objective To study the effect of SI-NI-SAN on bile component of postoperational patients of primary bile duct stone，probe into the mechanism of SI-NI-SAN in prevent of the form of primary bile duct stone，and develop the clinical adhibition of traditional medicine.Methods Total33patients who had suffered from primary bile duct stone underwent an opened abdominal operation to take away the stone ......