【摘要】 目的 研究亚硒酸钠(sodium selenite，Se)对大鼠脑缺血再灌注损伤的保护作用及其机制。 方法 采用大鼠急性不完全性脑缺血再灌注损伤模型，测定脑组织含水量、丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-PX)的含量。 结果 亚硒酸钠能显著对抗缺血再灌注大鼠脑组织含水量、MDA含量的升高(P<0.05，P<0.01)，SOD及GSH-PX活性的降低(P<0.05，P<0.01)。 结论 亚硒酸钠具有保护脑缺血再灌注性损伤的作用，机制与降低脑脂质过氧化和增强氧自由基清除酶的活性有关。

    关键词 亚硒酸钠 缺血再灌注损伤 超氧化物歧化酶 谷胱甘肽过氧化物酶

    Effects of sodium selenite on acute ischemia reperfusional brain lesion in rats

    Cheng Cailian，He Liya，Wang Xiaojuan，et al.

    Medical College，Wuhan University of Science and Technology，Wuhan430080.

    【Abstract】 Objective To study the protective effects and mechanism of sodium selenite against acute brain lesion induced by ischemia and reperfusional in rats.Methods The contents of water malondislehyde(MDA)and the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)in the brain tissue of rats were mea-sured on the cerebral ischemia-reperfusion lesion model，which was produced by30minutes of common carotid artery ligation following60minutes and180minutes of reperfusion in rats.Results Sodium selenite significantly an-tagonized the increase of water and MDA contents(P<0.05and0.01 ......