【摘要】 目的 观察干扰素α-1b联合拉米夫定治疗24周后慢性乙型肝炎患者血清学HBV-DNA等变化。 方法 130例慢性乙型肝炎患者均予α-1b干扰素(赛若金，深圳科兴生物制品公司)5MU，肌注，1次/d，第2个月后隔日1次，拉米夫定(英国Glaxowtllcome公司)100mg/d，连用24周。治疗中每月检测HBV-DNA含量，血清ALT、AST、HBsAg、HBeAg和抗-HBe。 结果 130例患者治疗后HBV-DNA全部阴性(<1.6pg/ml)，HBeAg阴转率84.6%(110/130)，抗-HBe阳转率66.7%(87/130)。 结论 干扰素联合拉米夫定可使HBV-DNA阴转，HBsAg、HBeAg表达量减少。

    关键词 慢性乙型肝炎 干扰素α-1b 拉米夫定 血清学

    A prospective study on serological changes after interferon alpha-1b and lamivudine treatments in chronic hepatitis B infection

    He Jie，Zhao Donghong，Zhao Donghui，et al.

    The222th Hospital of PLA，Jilin132011.

    【Abstract】 Objective To investigate the serological changes in HBV-DNA changes in sera induced by24weeks of interferon alpha-1b and lamivudine inpatients with chronic hepatitis B infection.Methods One hundred and thirty patients were enrolled into this prospective study.All patients had a liver biopsy with1week starting inter-feron therapy.Interferon alpha-1b was given at a dose of5MUthrice a week for4weeks;1month later became5MU thrice a week.One hundred and thirty chronic hepatitis B patients received100mg lamivudine orally daily for24weeks.HBV-DNA ......