吴江 孙莉 刘亢丁 陈琦 吴江 孙莉 刘亢丁(白求恩医科大学第一临床学院神经内科，吉林 长春 130021)；陈琦(长春市公安局医疗门诊部，吉林 长春 130061) 中风与神经疾病杂志 2000 0 17 4


    关键词：Ubiquitin；轴索变性；GAD小鼠 期刊 zfysjjbzz 0 203-205 论著与经验总结 fur -->


    

摘 要： 目的 探索GAD小鼠中枢神经系统的轴索变性和Ubiquitin的相互关系。方法 用免疫组织化学染色方法。结果 在GAD小鼠中枢神经系统的轴索变性部位，出现了多数Ubiquitin阳性的点状构造物(dot-likestructures:DS)。这种DS从9周龄开始，首先在构成薄束路和脊髓小脑后路的上行纤维的远端区域-薄束核区和小脑白质出现，逐渐按照延髓、颈髓、胸髓、腰髓的顺序，向细胞体方向逆行性地进展。18周龄时波及到锥体路，32周龄时进一步波及到丘脑和嗅觉、视觉、听觉传导路。结论 Ubiquitin阳性的DS作为病理构造物，是伴随着GAD小鼠中枢神经系统的轴索变性而出现特征性所见。根据其分布及数量可了解轴索变性的部位、程度及进展过程。

    中图分类号： R741.02 文献标识码： A 文章编号： 1003-2754(2000)04-0203-03

Therelationship between ubiquitin and axonal degeneration of GAD mice

WU Jiang SUN Li LIU Kang-ding et al.

    ( The First TeachingHospital of Norman Bethune University of Medical Sciences,Changchun 130021 China )

Abstract ： Objective To investigate the relationshipbetween Ubiquitin and axonal degeneration in the central nervous system (CNS) of thegracile axonal dystrophy (GAD) mutant mouse. Methods Using immunohistochemical technique in detecting. Results Many Ubiqintin-positive dot likestructures (DS) were observed in the CNS of the GAD mice. These DSs were first observed at9 weeks in the distal part of ascending fibers that consist of gracile fasciculus andcerebellospinal-gracile nucleus and white matter of cerebellum. They extend along medullaoblongate to medulla cervix 、 medulla thorax 、 medulla lumbalis in accordance with dying-back type degeneration. Thecorticospinal tract were affected at 18 weeks,and thalamus 、 the olfactory pathway 、 the visal pathway 、 the auditory pathway were affected at 32 weeks. Conclusion As a pathologic structure,theUbiqintin-positive DS was characteristic change in axonal degeneration in the CNS of GADmice. It ^......

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