牛国忠 卢国跃 华洁 顾小林 金石 310006 杭州市第一人民医院神经科 中风与神经疾病杂志 1999 0 16 2


    关键词：亚低温；脑出血；死亡率；钙 期刊 zfysjjbzz 0 论著与经验总结 fur -->


    

摘 要 目的 本研究观察32℃亚低温对实验性脑出血大鼠24h内死亡率和脑组织钙含量的影响。方法 134只大鼠分成两部分：(1)68只大鼠用于死亡率观察；(2)66只大鼠用于脑组织钙含量测定。每一部分分成假手术对照组、常温脑出血组及亚低温脑出血组。结果 常温组24h内死亡率为36.67%，亚低温组为4.55%；脑组织钙含量常温组较对照组和亚低温组为高。结论 亚低温治疗能显著减少实验性脑出血大鼠24h内死亡率，减少脑出血后脑组织钙含量。

Moderate hypothermiareduce the mortality and

    the content of calcium in the brain after experimental

    cerebral hemorrhage in rats.

Niu Guozhong,Lu Guoyue,Hua Jie,etal.

    Department of Neurology,Hangzhou First People^, s Hospital,Hangzhou 310006

Abstract Objective To study the effects of moderatehypothermia on the mortality during twenty-four hours and the content of calcium in thebrain after experimental cerebral hemorrhage in rats.Method Of 134 rats were divided into twoparts:(1)68 rats were used for observing of the mortality,(2)66 rats were used fordetermining the content of calcium in the brain.Every part was divided into threegroups:(1)sham-operated group,(2)nor-morthermic group (37℃),(3)hypothermic group(32℃ ).Results During 24 hours after cerebral hemorrhage,the mortality is36.67% in the normothermic group, and it is 4.55% in the hypothermic group.In thenormothermic group,the content of calcium is remarkablely highter than that of thesham-operated group and the hypothermic group.Conclusion Hypothermic therapy can reducethe mortality and the content of calcium in the brain after experimental cerebralhemorrhage in rats.

     Key words Hypothermia Cerebral hemorrhage Motality Calcium

自Busto^[1] 首先报道了轻度低温对脑缺血大鼠海马CA₁ 神经元有显著保护作用以来 ......

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