戊四氮_癫痫_胶原纤维酸性蛋白_大鼠(论著与经验总结)

戊四氮致痫对大鼠海马星形胶质细胞的影响

http://www.100md.com 《中风与神经疾病杂志》 1999年第5期

戊四氮|癫痫|胶原纤维酸性蛋白|大鼠,关键词：

     王玉阮旭中 430030 武汉同济医科大学附属同济医院神经内科中风与神经疾病杂志 1999 0 16 5

    关键词：戊四氮；癫痫；胶原纤维酸性蛋白；大鼠期刊 zfysjjbzz 0 论著与经验总结 fur -->

摘要 目的探讨戊四氮(PTZ)致痫对大鼠海马星形胶质细胞的影响。方法应用免疫组织化学方法观察PTZ致痫后大鼠海马内胶原纤维酸性蛋白(GFAP)变化的特点，同时观察了不同强度的痫性发作与GFAP改变的关系。结果 GFAP改变于PTZ致痫后12h开始，24h达到高峰，72h已开始回落，并且痫性发作的强度与GFAP改变有一定的联系。结论癫痫与星形细胞之间确有一定联系。

Effect of epilepticseizure induced by PTZ on the hippocampal astrocytes in rats

Wang Yu,Ruan Xuzhong

(Department of Neurology,Tongji Medical University,Wuhan 430030)

Abstract Objective To explorethe effect of epileptic seizure induced by pentylenetetrazol (PTZ) on the hippocampalastrocytes.Methods The time charactery of glial fibrillary acidicprotein (GFAP) in hippocampus was observed in rats following administration with PTZ,viaimmunocytochemistry.Simultaneously,the relationship between seizure degree and GFAP wasobserved too.Results After the rats were administered with PTZ,GFAPchange began at 12h,reached peak at 24h and began its reduction at 72h,and GFAP changeswere associated with seizure degrees.Conclusion Epileptic seizure isprecisely associated with astrocyte changes.

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