@血塞通胶丸_药理学_脑缺血_药物作用(药效与毒理学研究)

血塞通胶丸对脑缺血的保护作用

http://www.100md.com 《中药新药与临床药理》 1999年第4期

@血塞通胶丸,药理学|脑缺血,药物作用,关键词：,ProtectiveEffectofXuesaitongCapsuleonCerebralIschemia

     张华明李辉王成军方春生杨再康赖泳刘晓波大理医学院药理学教研室，云南大理671000 中药新药与临床药理 1999 0 10 4

    关键词：@血塞通胶丸/药理学；脑缺血/药物作用期刊 zyxyylcyl 0 药效与毒理学研究 fur -->

摘要： 用结扎颈总动脉合并降压法制备的脑缺血模型研究中药血塞通胶丸对脑缺血的保护作用。结果显示，给药后缺血大鼠的脑含水量、脑毛细胞管通透性、脑组织的缺血损伤程度均明显降低。另外，该药能明显提高小鼠的耐缺氧能力，提示血塞通胶丸有明显的脑缺血保护作用。

中图分类号：R285.5

文献标认码：A 文章编号：1003-9783(1999)04-0223-03

Protective Effect of Xuesaitong Capsule on Cere bral Ischemia

ZHANG Huaming,LI Hui,WANG Chengjun,et al.

(Dept.of Pharmacology,Dali Medical College,Dali 671000)

Abstract: The protective effect of Xuesait ong Capsule (XC) on cereb ral ischemia were studied in rat model established by ligation of bilateral caro tid arteries and lowering of blood pressure.The results showed that XC at the dose of 0.1g/kg and 0.2g/kg significantly decre ased the water content,permeability of capillary and ischemic injury in brain.In addition,XC significantly increased hypoxie tolerance in mice at the dose of 0.2g/kg.The results indicate that XC exerts a protective effect on acute cerebral ischemic injury.

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