王智楠 徐忠强 王淑芬 鲁建生 冯亭 王竞春 王智楠(武汉市儿童医院耳鼻咽喉科 武汉，430016)；徐忠强(武汉市儿童医院耳鼻咽喉科 武汉，430016)；王淑芬(武汉市儿童医院耳鼻咽喉科 武汉，430016)；鲁建生(武汉市儿童医院病理科 武汉，430016)；冯亭(武汉市儿童医院病理科 武汉，430016)；王竞春(武汉市儿童医院病理科 武汉，430016) 临床耳鼻咽喉科杂志 2000 0 14 3


    关键词：慢性扁桃体炎；角化；角蛋白 期刊 lcebyhkzz 0 122-123 临床研究 fur -->


    

摘 要 ：目的：探讨慢性扁桃体炎患儿扁桃体隐窝上皮的变化。方法：将摘除的230例扁桃体均以10%福尔马林固定，常规石蜡包埋切片，HE染色，并行抗隐窝上皮角质蛋白(CK)免疫组化检测，观察小儿慢性扁桃体炎症变化。结果：230例扁桃体隐窝上皮明显角化209例(90.9%)，未见角化21例(9.1%)；3例隐窝底部有霉菌菌丝和细菌；扁桃体隐窝上皮抗广谱和高分子CK均呈阳性反应，全组隐窝内角化物抗广谱CK亦均呈阳性反应。结论：小儿扁桃体每次炎症病变，都使扁桃体上皮进行性破坏，扁桃体产生免疫球蛋白的物质减少，因而不能有效发挥保护作用，而细菌、病毒等物质却可顺利通过化生性上皮向上皮下侵犯，这种周而复始的恶性循环，只有施行扁桃体切除术方能阻断。

Immunologic histochemical observation of anti-crypt keratin of cryptic

    epithelium of tonsilla in children with chronic tonsillitis

WANG Zhi-nan XU Zhong-qiang WANG Shu-fen

    ( Department of Otorhinolaryngology, Wuhan Children′ s Hospital,Wuhan 430016)

    LU Jian-sheng FENG Ting WANG Jing-chun

    ( Department of Pathology,Wuhan Children′ s Hospital)

Abstract ： Objective :To investigate anti-crypt keratin (CK) immunologic histochemical changes in children with chronic tonsillitis.Method :Removed tonsilla were fixed by 10% formaldehyde.Immunologic histochemical method was used to determine the changes of anti-broad spectrum (KD 68、 56、 56、 50) CKSP^TM .Result :In 230 cases,obvious keratosis was 90.9%,no keratosis was 9.1%,3 cases were found with fungus filaments and bacteria in the bottom of crypts.Anti-broad spectrum and hypermolecule CK of tonsil cryptic epithelium were positive reaction,anti-broad spectrum CK of cryptic keratosis in all cases was positive reaction.Conclusion :During the period of episode,cryptic epitheliums of tonsilla was destroyed repeatly,therefore,immunoglobulin production was reduce.Because the immune function of tonsilla was reduced,bacteria and virus might be invade into organism.This reduplicative malignant circles must be interupted or blocked only by tonsillectomy.

    Key words ： Chronic tonsillitis Keratosis Keratin▲

人类口腔粘膜除硬腭外一般无角化 ......