关键词：脑血管病变；基因；血管紧张素I转换酶；高血压史
摘要：目的 从分子生物学的角度探讨血管紧张素I转换酶(ACE)基因型变化及高血压参与临床急性脑血管病(ACVD)的分子生物学机理的可能性。方法 对203例ACVD患者和51例对照组的外显子16片段进行PCR扩增，检测扩增的DNA条带，进行统计分析。结果 有高血压史伴ACE基因的脑梗死(AI)发生率显著高于ACE基因阴性的患者结论 ACE基因多态性与ACVD无关，但高血压 史伴ACE基因多态性是AI发生的致危因素之一，DD型ACE基因的患者中高血压的有无之比为10：2。
中图分类号：R743 文献标识码：A
文章编号：100 7-5496(2000)10-1504-02
Study of ACE gene andhypertension on mechanism of CVD
QIU Xiu lan,ZHANG Xiao ling,TANGYang jie,et al.
Abstract:Objective Our research is aimed to study apossible involvement of ACE gene types and hypertension upon the molccular mechanism ofclinic ACVD.Method Using a PCR,a DNA fragment of intron 16 of ACE gene was studied in 203 patientswith ACVD and 51 control samples.Result Patients with hypertension and ACE DDallele.showed more significant AI incidence than those with hypertension and ACE Ⅱallele.Conclusion Our study suggests that ACE gene polymorphism combined withhypertension is a possible molecular mechanism underlying AI.
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