刘飞 章翔 曹卫东 梁景文 刘飞(第四军医大学西京医院神经外科中国人民解放军神经外科研究所 西安市 710032)；章翔(第四军医大学西京医院神经外科中国人民解放军神经外科研究所 西安市 710032)；曹卫东(第四军医大学西京医院神经外科中国人民解放军神经外科研究所 西安市 710032)；梁景文(第四军医大学西京医院神经外科中国人民解放军神经外科研究所 西安市 710032) 中国肿瘤临床 2000 0 27 6


    关键词：垂体腺瘤蛋白质p16侵袭 期刊 zgzllc 0 论著 fur -->


    

刘飞 章翔 曹卫东 梁景文

摘要：目的:探讨垂体腺瘤侵袭及复发与抑癌基因p16蛋白表达的关系。方法：通过免疫组化方法检测57例垂体腺瘤中p16蛋白的表达水平，并对患者进行5年随访对比研究。结果:垂体腺瘤组织中p16蛋白阳性率为31.6%，侵袭性组p16蛋白阳性率显著低于非侵袭性组(P<0.01)。11例复发组p16蛋白阳性率为0，显著低于41例未复发组p16蛋白阳性率36.6%(P<0.01)。不同激素分泌功能垂体腺瘤p16蛋白表达率无显著差异。结论:p16蛋白表达水平可作为临床评价垂体腺瘤侵袭性和预测患者复发的指标。

Clinical Significance of Expression of p16 Protein in Pituitary Adenomas

Liu Fei Zhang Xiang Cao Weidong et al

    (Department of Neurosurgery,Xijing Hospital,Fourth Military Medical University,Xi′ an)

Abstract Objective:To study the correlation between invasiveness and recurrence of pituitary adenomas and the expression of p16 protein.Methods:Immunohistochemical method was adopted to detect the expression of p16 protein in 57 cases of pituitary adenomas.Five-year follow-up research work was carried out for the patients.Results:Positive staining of p16 protein was found in 31.6% of all cases.The percentage of p16-positive adenomas in invasive group was significantly lower than that in noninvasive group (P<0.01).p16 positive rate of 11 recurrent adenomas was 0% which was significantly lower than that of 41 non-recurrent adenomas (36.6% ) (P< 0.01).Pituitary adenomas with different secretive functions showed no difference in the expression of p16 protein.Conclusion:The Detection of p16 protein expression may be a useful indicator for clinically evaluating invasiveness and recurrence of pituitary adenomas.

    Key Words Pituitary adenoma p16 Protein

p16基因是近年来发现的与细胞周期调控密切相关的抑癌基因 ......

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